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quarterly holdings since 2019, from its SEC Form N-PORT filings, TickerInside, https://tickerinside.com/api/v1/quarterly/ibb.json","answer":"In IBB's SEC filings, its largest position went from CELG at 8.47% on 2019-09-30 to Vertex Pharmaceuticals (VRTX) at 8.08% on 2026-06-30, across 28 quarterly reports."}