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quarterly holdings since 2019, from its SEC Form N-PORT filings, TickerInside, https://tickerinside.com/api/v1/quarterly/pbe.json","answer":"In PBE's SEC filings, its largest position went from Biogen (BIIB) at 6.66% on 2019-10-31 to Regeneron Pharmaceuticals (REGN) at 5.47% on 2026-07-31, across 28 quarterly reports."}