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quarterly holdings since 2019, from its SEC Form N-PORT filings, TickerInside, https://tickerinside.com/api/v1/quarterly/xbi.json","answer":"In XBI's SEC filings, its largest position went from SGEN at 2.09% on 2019-09-30 to APGE at 1.49% on 2026-06-30, across 28 quarterly reports."}