# PBE holdings and overlap

Invesco Biotechnology & Genome ETF, Health Care, Invesco.

Canonical page: https://tickerinside.com/etf/pbe/
Holdings from the issuer file published 2026-09-05. Prices through 2026-09-04.
Licence: CC BY 4.0, attribution to TickerInside. Measurements, not investment advice.

## Largest positions, issuer file of 2026-09-05

| Rank | Ticker | Company | Weight |
| --- | --- | --- | --- |
| 1 | RPRX | Royalty Pharma PLC | 5.22% |
| 2 | GILD | Gilead Sciences Inc | 5.13% |
| 3 | BIIB | Biogen Inc | 5.05% |
| 4 | AMGN | Amgen Inc | 5.02% |
| 5 | REGN | Regeneron Pharmaceuticals Inc | 5.02% |
| 6 | VRTX | Vertex Pharmaceuticals Inc | 4.99% |
| 7 | NTRA | Natera Inc | 4.92% |
| 8 | ILMN | Illumina Inc | 4.9% |
| 9 | SRPT | Sarepta Therapeutics Inc | 3.28% |
| 10 | NVAX | Novavax Inc | 2.98% |
| 11 | EXEL | Exelixis Inc | 2.87% |
| 12 | NBIX | Neurocrine Biosciences Inc | 2.8% |
| 13 | BCRX | BioCryst Pharmaceuticals Inc | 2.79% |
| 14 | LEGN | Legend Biotech Corp | 2.78% |
| 15 | TGTX | TG Therapeutics Inc | 2.78% |
| 16 | HALO | Halozyme Therapeutics Inc | 2.78% |
| 17 | BMRN | BioMarin Pharmaceutical Inc | 2.77% |
| 18 | ARDX | Ardelyx Inc | 2.75% |
| 19 | QGEN | Qiagen NV | 2.74% |
| 20 | INCY | Incyte Corp | 2.69% |
| 21 | ANAB | AnaptysBio Inc | 2.68% |
| 22 | PTGX | Protagonist Therapeutics Inc | 2.67% |
| 23 | VCYT | Veracyte Inc | 2.66% |
| 24 | PTCT | PTC Therapeutics Inc | 2.6% |
| 25 | UTHR | United Therapeutics Corp | 2.59% |

All 30 positions with weights: https://tickerinside.com/api/v1/fund/pbe.json

## Key figures

| Measure | Value |
| --- | --- |
| Last close, 2026-09-04 | 97.64 USD (-1.09% on the day) |
| Expense ratio | 0.58% |
| Positions | 30 |
| Weight in the ten largest | 46.5% |
| Total return, 1 year | 40.2% |
| Total return, 3 years | 66.6% |
| Volatility, annualised | 19.6% |
| Worst fall, 3 years | -19.0% |
| Beta against SPY | 0.75 |
| Assets | $0.5B |

## What does PBE share with other funds?

| Fund | Overlap by weight | Of PBE held there | Of that fund in PBE | Companies in both |
| --- | --- | --- | --- | --- |
| IBB | 40.6% | 84.1% | 52.0% | 25 |
| IBBQ | 37.8% | 87.0% | 49.0% | 26 |
| BMED | 27.6% | 41.3% | 29.6% | 11 |
| XBI | 24.9% | 79.4% | 25.4% | 24 |
| PJP | 21.2% | 25.2% | 22.4% | 6 |
| IDNA | 17.1% | 21.1% | 25.2% | 6 |
| IYH | 14.8% | 64.6% | 14.9% | 17 |
| IBRN | 14.5% | 16.3% | 18.7% | 5 |
| PSCH | 14.3% | 21.4% | 17.4% | 8 |
| RSPH | 13.3% | 30.4% | 15.4% | 7 |
| XLV | 12.2% | 30.4% | 12.2% | 7 |
| VHT | 11.9% | 89.2% | 11.9% | 27 |


Method: https://tickerinside.com/how-the-numbers-are-produced/