# XBI holdings and overlap

SPDR S&P Biotech ETF, Health Care, SPDR.

Canonical page: https://tickerinside.com/etf/xbi/
Holdings from the issuer file published 2026-09-03. Prices through 2026-09-04.
Licence: CC BY 4.0, attribution to TickerInside. Measurements, not investment advice.

## Largest positions, issuer file of 2026-09-03

| Rank | Ticker | Company | Weight |
| --- | --- | --- | --- |
| 1 | MRNA | Moderna Inc | 2.98% |
| 2 | TWST | Twist Bioscience Corp | 1.75% |
| 3 | HALO | Halozyme Therapeutics Inc | 1.45% |
| 4 | NTRA | Natera Inc | 1.4% |
| 5 | KYMR | Kymera Therapeutics Inc | 1.38% |
| 6 | PRAX | Praxis Precision Medicines I | 1.36% |
| 7 | RVMD | Revolution Medicines Inc | 1.35% |
| 8 | TVTX | Travere Therapeutics Inc | 1.31% |
| 9 | ORKA | Oruka Therapeutics Inc | 1.31% |
| 10 | DNTH | Dianthus Therapeutics Inc | 1.3% |
| 11 | PTGX | Protagonist Therapeutics Inc | 1.3% |
| 12 | REGN | Regeneron Pharmaceuticals | 1.29% |
| 13 | INSM | Insmed Inc | 1.27% |
| 14 | CGON | CG Oncology Inc | 1.25% |
| 15 | PCVX | Vaxcyte Inc | 1.24% |
| 16 | AMGN | Amgen Inc | 1.21% |
| 17 | SMMT | Summit Therapeutics Inc | 1.18% |
| 18 | VRTX | Vertex Pharmaceuticals Inc | 1.18% |
| 19 | IOVA | Iovance Biotherapeutics Inc | 1.17% |
| 20 | SRRK | Scholar Rock Holding Corp | 1.17% |
| 21 | GILD | Gilead Sciences Inc | 1.15% |
| 22 | VKTX | Viking Therapeutics Inc | 1.13% |
| 23 | RYTM | Rhythm Pharmaceuticals Inc | 1.13% |
| 24 | ARWR | Arrowhead Pharmaceuticals in | 1.13% |
| 25 | TGTX | TG Therapeutics Inc | 1.12% |

All 148 positions with weights: https://tickerinside.com/api/v1/fund/xbi.json

## Key figures

| Measure | Value |
| --- | --- |
| Last close, 2026-09-04 | 163.81 USD (-0.35% on the day) |
| Expense ratio | 0.35% |
| Positions | 148 |
| Weight in the ten largest | 15.6% |
| Total return, 1 year | 72.4% |
| Total return, 3 years | 109.6% |
| Volatility, annualised | 27.6% |
| Worst fall, 3 years | -29.3% |
| Beta against SPY | 1.08 |
| Assets | $11.4B |

## What does XBI share with other funds?

| Fund | Overlap by weight | Of XBI held there | Of that fund in XBI | Companies in both |
| --- | --- | --- | --- | --- |
| IBBQ | 41.4% | 83.7% | 73.7% | 115 |
| IBB | 41.2% | 86.3% | 75.8% | 120 |
| PBE | 24.9% | 25.4% | 79.4% | 24 |
| PTH | 24.6% | 24.7% | 47.1% | 23 |
| BMED | 20.4% | 24.8% | 39.2% | 22 |
| IDNA | 19.9% | 20.2% | 55.4% | 24 |
| IBRN | 14.6% | 14.7% | 56.0% | 22 |
| IWO | 13.8% | 61.9% | 14.0% | 99 |
| VHT | 13.4% | 96.0% | 22.4% | 133 |
| VTWG | 13.3% | 61.9% | 13.3% | 99 |
| IYH | 12.1% | 28.7% | 23.4% | 24 |
| RSPH | 11.1% | 11.1% | 17.0% | 8 |


Method: https://tickerinside.com/how-the-numbers-are-produced/