# XPH holdings and overlap

State Street SPDR S&P Pharmaceuticals ETF, Health Care, SPDR.

Canonical page: https://tickerinside.com/etf/xph/
Holdings from the issuer file published 2026-09-03. Prices through 2026-09-04.
Licence: CC BY 4.0, attribution to TickerInside. Measurements, not investment advice.

## Largest positions, issuer file of 2026-09-03

| Rank | Ticker | Company | Weight |
| --- | --- | --- | --- |
| 1 | AMLX | Amylyx Pharmaceuticals Inc | 3.8% |
| 2 | MBX | MBX Biosciences Inc | 2.98% |
| 3 | ATAI | Ataibeckley Inc | 2.92% |
| 4 | OMER | Omeros Corp | 2.82% |
| 5 | DFTX | Definium Therapeutics Inc | 2.46% |
| 6 | ELVN | Enliven Therapeutics Inc | 2.43% |
| 7 | NUVB | Nuvation Bio Inc | 2.22% |
| 8 | CORT | Corcept Therapeutics Inc | 2.17% |
| 9 | ETON | Eton Pharmaceuticals Inc | 2.13% |
| 10 | TARS | Tarsus Pharmaceuticals Inc | 2.04% |
| 11 | NKTR | Nektar Therapeutics | 2.02% |
| 12 | [MRK](https://tickerinside.com/stock/mrk/) | Merck + Co. Inc. | 1.92% |
| 13 | PRGO | Perrigo Co PLC | 1.92% |
| 14 | EWTX | Edgewise Therapeutics Inc | 1.92% |
| 15 | TRVI | Trevi Therapeutics Inc | 1.92% |
| 16 | BMY | Bristol Myers Squibb Co | 1.84% |
| 17 | OCUL | Ocular Therapeutix Inc | 1.83% |
| 18 | HRMY | Harmony Biosciences Holdings | 1.78% |
| 19 | RPRX | Royalty Pharma PLC | 1.76% |
| 20 | [JNJ](https://tickerinside.com/stock/jnj/) | Johnson + Johnson | 1.76% |
| 21 | LGND | Ligand Pharmaceuticals | 1.76% |
| 22 | AMRX | Amneal Pharmaceuticals Inc | 1.76% |
| 23 | PCRX | Pacira Biosciences Inc | 1.71% |
| 24 | PFE | Pfizer Inc | 1.69% |
| 25 | JAZZ | Jazz Pharmaceuticals PLC | 1.62% |

All 63 positions with weights: https://tickerinside.com/api/v1/fund/xph.json

## Key figures

| Measure | Value |
| --- | --- |
| Last close, 2026-09-04 | 70.93 USD (-0.14% on the day) |
| Expense ratio | 0.35% |
| Positions | 63 |
| Weight in the ten largest | 26.0% |
| Total return, 1 year | 49.2% |
| Total return, 3 years | 70.9% |
| Volatility, annualised | 20.1% |
| Worst fall, 3 years | -21.1% |
| Beta against SPY | 0.76 |
| Assets | $0.6B |

## What does XPH share with other funds?

| Fund | Overlap by weight | Of XPH held there | Of that fund in XPH | Companies in both |
| --- | --- | --- | --- | --- |
| IHE | 37.9% | 91.3% | 100.0% | 55 |
| PJP | 32.2% | 32.2% | 67.0% | 19 |
| PSCH | 17.6% | 25.5% | 24.1% | 16 |
| PTH | 16.4% | 22.4% | 19.8% | 12 |
| VHT | 11.2% | 89.2% | 33.5% | 55 |
| RSPH | 11.2% | 11.8% | 11.2% | 7 |
| IYH | 10.7% | 21.8% | 37.1% | 13 |
| IBBQ | 9.8% | 69.5% | 9.8% | 44 |
| XLV | 9.6% | 11.8% | 37.2% | 7 |
| IXJ | 9.2% | 11.8% | 26.2% | 7 |
| IBRN | 8.5% | 9.7% | 12.9% | 7 |
| BMED | 8.3% | 11.5% | 14.3% | 6 |


Method: https://tickerinside.com/how-the-numbers-are-produced/