# Which ETFs hold Twist Bioscience (TWST)?

82 US stock ETFs hold Twist Bioscience (TWST). 25 of them report TWST in issuer files dated 2026-10-01 to 2026-10-16, and 57 in their latest SEC filing, for periods ended 2026-05-31 to 2026-07-31. Among them, ARKG gives TWST the largest weight, 7.73% (SEC filing for the period ended 2026-07-31). Seven derivative-based funds and four funds read from their sponsors' files also hold TWST outright and are listed apart; HLTH gives it the most weight among them, 4.82% (Tema file of 2026-10-16).

Twist Bioscience, $9B market cap. Held by 82 US stock ETFs: 25 in issuer files, 57 in SEC filings. 11 other ETFs holding it outright are listed apart.

Canonical page: https://tickerinside.com/stock/twst/
Holdings from each issuer's latest file, dated 2026-10-01 to 2026-10-16, and from each other ETF's latest SEC filing, for periods ended 2026-05-31 to 2026-07-31. Prices through 2026-10-16.
Licence: CC BY 4.0, attribution to TickerInside. Measurements, not investment advice.

TWST is the single largest position in 4 of them: WDNA, FRTY, HAPS and KOMP. The median weight across the 82 holders is 0.24%: 4 of them carry it above 5% and 64 keep it under 1%. Of the 311 covered funds with 500 or more positions, 45 hold TWST, at weights from under 0.01% to 1.59%.

Over three years TWST returned 803.5%, with a worst fall of 56.4% and annualised volatility of 78.5%; its beta against SPY over the same weeks is 2.19. Its best calendar year in the data is 2026 at +377.1% and its worst 2022 at -69.2%.

## Is TWST in VOO, SPY, IVV, QQQ, VTI, SCHD, IBB, XBI or FHLC?

TWST is in 4 of these 9 funds; XBI gives it the most weight, 1.74% (SPDR file of 2026-10-15), and VOO, SPY, IVV, QQQ and SCHD do not hold it.

| ETF | Name | Weight | Rank in the ETF | Holdings dated |
| --- | --- | --- | --- | --- |
| VOO | Vanguard S&P 500 ETF | not held | 504 positions | SEC filing, 2026-06-30 |
| SPY | SPDR S&P 500 ETF Trust | not held | 504 positions | SPDR file, 2026-10-15 |
| IVV | iShares Core S&P 500 ETF | not held | 505 positions | iShares file, 2026-10-15 |
| QQQ | Invesco QQQ Trust | not held | 101 positions | Invesco file, 2026-10-15 |
| VTI | Vanguard Total Stock Market ETF | 0.01% | #892 of 3483 | SEC filing, 2026-06-30 |
| SCHD | Schwab US Dividend Equity ETF | not held | 99 positions | SEC filing, 2026-05-31 |
| IBB | iShares Biotechnology ETF | 0.66% | #30 of 237 | iShares file, 2026-10-15 |
| XBI | SPDR S&P Biotech ETF | 1.74% | #3 of 159 | SPDR file, 2026-10-15 |
| FHLC | Fidelity MSCI Health Care Index ETF | 0.07% | #112 of 333 | SEC filing, 2026-07-31 |

## Which ETFs hold TWST in their issuer files, and at what weight?

25 funds report TWST in their own issuer files, dated 2026-10-01 to 2026-10-16; GNOM gives it the most weight, 6.05%.

| Rank | ETF | Name | Weight | Issuer file |
| --- | --- | --- | --- | --- |
| 1 | GNOM | Global X Genomics & Biotechnology ETF | 6.05% | 2026-10-16 |
| 2 | IDNA | iShares Genomics Immunology and Healthcare ETF | 5.82% | 2026-10-15 |
| 3 | PTH | Invesco Dorsey Wright Healthcare Momentum ETF | 2.92% | 2026-10-15 |
| 4 | XBI | SPDR S&P Biotech ETF | 1.74% | 2026-10-15 |
| 5 | KOMP | State Street SPDR S&P Kensho New Economies Composite ETF | 1.59% | 2026-10-15 |
| 6 | DWAS | Invesco Dorsey Wright SmallCap Momentum ETF | 0.78% | 2026-10-15 |
| 7 | IBB | iShares Biotechnology ETF | 0.66% | 2026-10-15 |
| 8 | IWO | iShares Russell 2000 Growth ETF | 0.65% | 2026-10-15 |
| 9 | IBBQ | Invesco Nasdaq Biotechnology ETF | 0.64% | 2026-10-15 |
| 10 | IWM | iShares Russell 2000 ETF | 0.32% | 2026-10-15 |
| 11 | IWMW | iShares IWM Premium Income+ ETF | 0.32% | 2026-10-15 |
| 12 | RSSL | Global X Russell 2000 ETF | 0.30% | 2026-10-16 |
| 13 | ISCG | iShares Morningstar Small-Cap Growth ETF | 0.29% | 2026-10-15 |
| 14 | OMFS | Invesco Russell 2000 Dynamic Multifactor ETF | 0.25% | 2026-10-15 |
| 15 | SMLF | iShares U.S. Small-Cap Equity Factor ETF | 0.24% | 2026-10-15 |
| 16 | ISCB | iShares Morningstar Small-Cap ETF | 0.19% | 2026-10-01 |
| 17 | PRFZ | Invesco RAFI US 1500 Small-Mid ETF | 0.18% | 2026-10-15 |
| 18 | TECB | iShares U.S. Tech Breakthrough Multisector ETF | 0.16% | 2026-10-15 |
| 19 | ESML | iShares ESG Aware MSCI USA Small-Cap ETF | 0.14% | 2026-10-15 |
| 20 | SMMD | iShares Russell 2500 ETF | 0.13% | 2026-10-15 |
| 21 | MSML | iShares MSCI USA Small-Cap ETF | 0.13% | 2026-10-15 |
| 22 | WSML | iShares MSCI World Small-Cap ETF | 0.08% | 2026-10-15 |
| 23 | SPGM | State Street SPDR Portfolio MSCI Global Stock Market ETF | 0.02% | 2026-10-15 |
| 24 | ITOT | iShares Core S&P Total U.S. Stock Market ETF | 0.01% | 2026-10-15 |
| 25 | IWV | iShares Russell 3000 ETF | 0.01% | 2026-10-15 |

The same list as JSON: https://tickerinside.com/api/v1/sec/twst.json

## Which ETFs hold TWST in their latest SEC filing?

57 funds hold TWST in their latest Form N-PORT filing with the SEC, for periods ended 2026-05-31 to 2026-07-31; ARKG gives it the most weight, 7.73%.

| ETF | Name | Weight | Period of the filing | Filing |
| --- | --- | --- | --- | --- |
| ARKG | ARK Genomic Revolution ETF | 7.73% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1579982/000094040026037946/ |
| WDNA | WisdomTree BioRevolution Fund | 5.95% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1350487/000094040026036216/ |
| FRTY | Alger Mid Cap 40 ETF | 4.79% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1807486/000094040026035180/ |
| ARKK | ARK Innovation ETF | 3.31% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1579982/000094040026037955/ |
| HAPS | Harbor Human Capital Factor US Small Cap ETF | 2.86% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1860434/000141036826099277/ |
| HELX | Franklin Genomic Advancements ETF | 2.85% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1655589/000094040026035124/ |
| HTEC | ROBO Global Healthcare Technology and Innovation ETF | 2.23% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1452937/000204825126008259/ |
| EKG | First Trust Nasdaq Lux Digital Health Solutions ETF | 2.08% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1364608/000094040026032750/ |
| GNMX | Corgi Genomics & Precision Medicine ETF | 2.05% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/2078265/000089418926024712/ |
| PCSG | Polen 5Perspectives Small-Mid Growth ETF | 1.78% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1388485/000094040026037916/ |
| TSME | Thrivent Small-Mid Cap Equity ETF | 1.38% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1896670/000141036826085927/ |
| LFSC | F/m Emerald Life Sciences Innovation ETF | 1.14% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/831114/000119312526319618/ |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 1.03% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1552740/000094040026032714/ |
| SCDS | JPMorgan Fundamental Data Science Small Core ETF | 0.82% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1485894/000207169126021066/ |
| MMSC | First Trust Multi-Manager Small Cap Opportunities ETF | 0.79% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1667919/000094040026027828/ |
| SGRW | Harbor Active Small Cap Growth ETF | 0.63% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1860434/000141036826099259/ |
| JSML | Janus Henderson Small Cap Growth Alpha ETF | 0.61% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1500604/000207169126023366/ |
| FYC | First Trust Small Cap Growth AlphaDEX Fund | 0.60% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1383496/000094040026037859/ |
| ESSC | Eventide Small Cap ETF | 0.45% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1506213/000100472626009408/ |
| FSEG | Fidelity Enhanced Small Cap Growth ETF | 0.40% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/945908/000003540226005422/ |
| FYX | First Trust Small Cap Core AlphaDEX Fund | 0.28% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1383496/000094040026037832/ |
| TNXT | T. Rowe Price Innovation Leaders ETF | 0.27% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1795351/000109926326009634/ |
| FESM | Fidelity Enhanced Small Cap Core ETF | 0.26% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/945908/000003540226005400/ |
| PWS | Pacer WealthShield ETF | 0.26% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1616668/000089418926029039/ |
| STXK | Strive Small-Cap ETF | 0.25% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1592900/000159290026004163/ |
| BKSE | BNY Mellon US Small Cap Core Equity ETF | 0.24% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1493580/000094040026038307/ |
| ISMD | Inspire Small/Mid Cap ETF | 0.24% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1644419/000091047226011078/ |
| FFSM | Fidelity Fundamental Small-Mid Cap ETF | 0.24% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/945908/000003540226006162/ |
| VTWG | Vanguard Russell 2000 Growth ETF | 0.23% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1021882/000102188226000633/ |
| KBFR | Innovator U.S. Small Cap Managed 10 Buffer ETF | 0.22% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1415726/000089418926028378/ |
| BBSC | JPMorgan BetaBuilders U.S. Small Cap Equity ETF | 0.22% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1485894/000207169126023531/ |
| RFLR | Innovator U.S. Small Cap Managed Floor ETF | 0.20% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1415726/000089418926028381/ |
| RESM | Columbia Research Enhanced Small Cap ETF | 0.19% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/1551950/000141036826088918/ |
| WCEO | Hypatia Women CEO ETF | 0.17% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1552947/000091047226015127/ |
| VBK | Vanguard Morningstar Small-Cap Growth ETF | 0.17% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/36405/000003640526000483/ |
| FFF | Founders 100 ETF | 0.14% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/2077057/000089418926022403/ |
| FAD | First Trust Multi Cap Growth AlphaDEX Fund | 0.12% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1383496/000094040026037835/ |
| VTWO | Vanguard Russell 2000 ETF | 0.12% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1021882/000102188226000640/ |
| GINN | Goldman Sachs Innovate Equity ETF | 0.09% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1479026/000094040026028085/ |
| SCHA | Schwab U.S. Small-Cap ETF | 0.09% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1454889/000141036826075025/ |
| VXF | Vanguard Extended Market ETF | 0.08% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/36405/000003640526000478/ |
| FHLC | Fidelity MSCI Health Care Index ETF | 0.07% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/945908/000141036826097243/ |
| VB | Vanguard Small-Cap ETF | 0.07% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/36405/000003640526000472/ |
| VHT | Vanguard Health Care ETF | 0.06% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/52848/000005284826000886/ |
| GSSC | Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF | 0.05% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1479026/000094040026028081/ |
| DFAS | Dimensional U.S. Small Cap ETF | 0.04% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1816125/000100472626009202/ |
| MSSM | Morgan Stanley Pathway Small-Mid Cap Equity ETF | 0.02% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/875186/000100371526002828/ |
| ONEQ | Fidelity Nasdaq Composite Index ETF | 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/205323/000003540226004684/ |
| DFAC | Dimensional U.S. Core Equity 2 ETF | 0.01% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1816125/000100472626009214/ |
| TILT | FlexShares Morningstar US Market Factor Tilt Index Fund | 0.01% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1491978/000207169126023441/ |
| VTI | Vanguard Total Stock Market ETF | 0.01% | 2026-06-30 | https://www.sec.gov/Archives/edgar/data/36405/000003640526000480/ |
| GTPE | Goldman Sachs MSCI World Private Equity Return Tracker ETF | 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1479026/000094040026028139/ |
| ESGV | Vanguard ESG U.S. Stock ETF | 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/52848/000005284826000891/ |
| SCHB | Schwab U.S. Broad Market ETF | 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1454889/000141036826075044/ |
| VTHR | Vanguard Russell 3000 ETF | 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1021882/000102188226000642/ |
| VT | Vanguard Total World Stock ETF | under 0.01% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/857489/000085748926000275/ |
| AVTM | Avantis Total Equity Markets ETF | under 0.01% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1710607/000119312526324016/ |

## How many ETFs held TWST each year since 2019?

76 of today's US stock ETFs held TWST in their SEC reports for the second quarter of 2026, against 20 for the fourth quarter of 2019.

| Quarter | ETFs holding it | Largest weight |
| --- | --- | --- |
| Q4 2019 | 20 | DWAS 0.31% |
| Q4 2020 | 43 | XOVR 5.66% |
| Q4 2021 | 51 | ARKG 3.63% |
| Q4 2022 | 50 | ARKG 3.28% |
| Q4 2023 | 55 | WDNA 3.29% |
| Q4 2024 | 68 | ARKG 8.35% |
| Q4 2025 | 61 | ARKG 5.29% |
| Q2 2026 | 76 | ARKG 8.99% |

TWST in the SEC reports (Form N-PORT) of today's US stock ETFs, Q4 2019 to Q2 2026, every quarter in https://tickerinside.com/api/v1/sec/twst.json (etf_holders_since_2019). How these are counted: https://tickerinside.com/how-the-numbers-are-produced/#sec-history

## Which other ETFs hold TWST outright?

Seven derivative-based funds and four funds read from their sponsors' files hold TWST outright in SEC filings and sponsors' files dated 2026-05-31 to 2026-10-16; HLTH gives it the most weight, 4.82%. None of them is counted among the 82 US stock ETFs above.

| ETF | Name | Kind of ETF | Held outright | Holdings dated | Source |
| --- | --- | --- | --- | --- | --- |
| HLTH | Tema Healthcare AI ETF | Sponsor's file | 4.82% | 2026-10-16 | https://temaetfs.com/hubfs/Website/Holdings/HLTH-holdings-10162026.csv |
| CTAG | Calamos Timpani Active SMID Growth ETF | Sponsor's file | 1.38% | 2026-10-15 | https://www.calamos.com/downloadHoldings/F140/CTAGHoldings.csv |
| AESG | Harbor AlphaEdge Small Cap Growth ETF | Sponsor's file | 1.10% | 2026-10-15 | https://www.harborcapital.com/etf/aesg/ |
| LABU | Direxion Daily S&P Biotech Bull 3X Shares | Derivative-based | 0.92% | 2026-07-31 | https://www.sec.gov/Archives/edgar/data/1424958/000119312526404436/ |
| AESB | Harbor AlphaEdge Small Cap Core ETF | Sponsor's file | 0.70% | 2026-10-15 | https://www.harborcapital.com/etf/aesb/ |
| BIB | ProShares Ultra Nasdaq Biotechnology | Derivative-based | 0.21% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017441/ |
| RB | ProShares Russell 2000 Dynamic Buffer ETF | Derivative-based | 0.10% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017451/ |
| ITWO | ProShares Russell 2000 High Income ETF | Derivative-based | 0.10% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017331/ |
| UWM | ProShares Ultra Russell2000 | Derivative-based | 0.06% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017369/ |
| URTY | ProShares UltraPro Russell2000 | Derivative-based | 0.04% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017430/ |
| HDG | ProShares Hedge Replication ETF | Derivative-based | 0.02% | 2026-05-31 | https://www.sec.gov/Archives/edgar/data/1174610/000207169126017477/ |

## Key figures

| Measure | Value |
| --- | --- |
| Last close, 2026-10-13 | 151.33 USD (-0.35% on the day) |
| Total return, 1 year | 437.4% |
| Total return, 3 years | 803.5% |
| Total return, 5 years | 28.9% |
| Volatility, annualised | 78.5% |
| Worst fall, 3 years | -56.4% |
| Beta against SPY | 2.19 |
| Market cap | $8.8B |
| Dividend yield | 0.00% |
| US stock ETFs holding it | 82 |
| Broad ETFs holding it, 500 positions or more | 45 of 311 |
| $100 three years ago became | $903 |

## How has TWST done, year by year?

| Year | Total return |
| --- | --- |
| 2026 | 377.1% |
| 2025 | -31.7% |
| 2024 | 26.1% |
| 2023 | 54.8% |
| 2022 | -69.2% |

## What would diversify TWST?

The stocks that have moved least like TWST, among those held by ten or more covered ETFs, closed-end funds left out. A measurement of co-movement, not a suggestion.

| Ticker | Name | Correlation, 104 weeks | Reads as |
| --- | --- | --- | --- |
| CBOE | Cboe Global Markets | -0.22 | moves the opposite way |
| TPB | Turning Point Brands, Inc. | -0.18 | moves the opposite way |
| NFG | National Fuel Gas Company | -0.17 | moves the opposite way |
| PM | Philip Morris International | -0.17 | moves the opposite way |
| OXY | Occidental Petroleum | -0.17 | moves the opposite way |
| SU | Suncor Energy Inc. | -0.17 | moves the opposite way |

## What moves with TWST?

| Ticker | Name | Correlation, 104 weeks | Reads as |
| --- | --- | --- | --- |
| RGEN | Repligen Corporation | 0.60 | loosely linked |
| MLAB | Mesa Laboratories, Inc. | 0.57 | loosely linked |
| SDGR | Schrodinger, Inc. | 0.57 | loosely linked |
| TECH | Bio-Techne | 0.55 | loosely linked |
| AZTA | Azenta, Inc. | 0.55 | loosely linked |
| GFF | Griffon Corporation | 0.53 | loosely linked |

## Which ETF has the largest weight in TWST?

ARKG, at 7.73% in its SEC filing for the period ended 2026-07-31, where TWST is position #2 of 32, followed by GNOM at 6.05% and WDNA at 5.95%.

| ETF | Name | Weight | Rank in the ETF | Positions | Holdings dated |
| --- | --- | --- | --- | --- | --- |
| ARKG | ARK Genomic Revolution ETF | 7.73% | #2 | 32 | SEC filing, 2026-07-31 |
| GNOM | Global X Genomics & Biotechnology ETF | 6.05% | #3 | 50 | issuer file, 2026-10-16 |
| WDNA | WisdomTree BioRevolution Fund | 5.95% | #1 | 80 | SEC filing, 2026-06-30 |
| IDNA | iShares Genomics Immunology and Healthcare ETF | 5.82% | #2 | 47 | issuer file, 2026-10-15 |
| FRTY | Alger Mid Cap 40 ETF | 4.79% | #1 | 40 | SEC filing, 2026-06-30 |
| ARKK | ARK Innovation ETF | 3.31% | #10 | 44 | SEC filing, 2026-07-31 |
| PTH | Invesco Dorsey Wright Healthcare Momentum ETF | 2.92% | #9 | 52 | issuer file, 2026-10-15 |
| HAPS | Harbor Human Capital Factor US Small Cap ETF | 2.86% | #1 | 195 | SEC filing, 2026-07-31 |
| HELX | Franklin Genomic Advancements ETF | 2.85% | #9 | 61 | SEC filing, 2026-06-30 |
| HTEC | ROBO Global Healthcare Technology and Innovation ETF | 2.23% | #4 | 62 | SEC filing, 2026-07-31 |

## Cite this page

TickerInside, Twist Bioscience (TWST), holders from each covered fund's own file and from SEC Form N-PORT filings, each dated, prices through 2026-10-16, https://tickerinside.com/stock/twst/, CC BY 4.0

    <a href="https://tickerinside.com/stock/twst/">TickerInside</a> (https://tickerinside.com/stock/twst/)

Method: https://tickerinside.com/how-the-numbers-are-produced/