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IBRN holdings and overlap
What does IBRN hold, as of its issuer file of 2026-09-03?
IBRN holds 68 positions as of the issuer file dated 2026-09-03. The three largest are Praxis Precision Medicines at 5.23%, Dianthus Therapeutics Inc at 5.02% and Scholar Rock Holding at 4.73%.
| Rank | Company | Weight | Weight bar |
|---|---|---|---|
| 1 | PRAX Praxis Precision Medicines | 5.23% | |
| 2 | DNTH Dianthus Therapeutics Inc | 5.02% | |
| 3 | SRRK Scholar Rock Holding | 4.73% | |
| 4 | ACAD Acadia Pharmaceuticals | 4.71% | |
| 5 | ARWR Arrowhead Pharmaceuticals | 4.43% | |
| 6 | ARGX Argenx SE ADR | 4.43% | |
| 7 | XENE Xenon Pharmaceuticals | 4.37% | |
| 8 | BIIB Biogen | 4.3% | |
| 9 | ALKS Alkermes | 4.1% | |
| 10 | PTCT PTC Therapeutics | 3.77% | |
| 11 | NBIX Neurocrine Biosciences | 3.62% | |
| 12 | DNLI Denali Therapeutics | 3.39% | |
| 13 | AXSM Axsome Therapeutics | 3.36% | |
| 14 | DYN Dyne Therapeutics | 3.29% | |
| 15 | EWTX Edgewise Therapeutics | 3.29% | |
| 16 | 326030 SK Biopharmaceuticals Ltd | 2.48% | |
| 17 | AXGN Axogen | 2.43% | |
| 18 | SUPN Supernus Pharmaceuticals | 2.39% | |
| 19 | SRPT Sarepta Therapeutics | 2.32% | |
| 20 | BHVN Biohaven | 1.99% | |
| 21 | HLUN B H. Lundbeck | 1.85% | |
| 22 | NEU Neuren Pharmaceuticals | 1.62% | |
| 23 | BIOA B Bioarctic | 1.54% | |
| 24 | RAPP Rapport Therapeutics | 1.35% | |
| 25 | TSHA Taysha Gene Therapies | 1.32% | |
| 26 | ANRO Alto Neuroscience Inc | 1.14% | |
| 27 | IDIA Idorsia N Ltd | 1.13% | |
| 28 | IART Integra Lifesciences Holdings | 1.09% | |
| 29 | LBRX LB Pharmaceuticals Inc | 0.99% | |
| 30 | SLDB Solid Biosciences Inc | 0.81% | |
| 31 | DYVOX Dynavox Group | 0.8% | |
| 32 | ANNX Annexon | 0.69% | |
| 33 | 4588 Oncolys Biopharma Inc | 0.67% | |
| 34 | MEDCL Medincell SA | 0.63% | |
| 35 | CBLL Ceribell | 0.6% | |
| 36 | DSGN Design Therapeutics | 0.57% | |
| 37 | DRUG Bright Minds Biosciences | 0.51% | |
| 38 | CAPR Capricor Therapeutics | 0.48% | |
| 39 | NGNE Neurogene | 0.47% | |
| 40 | OVID Ovid Therapeutics | 0.46% | |
| 41 | PRTA Prothena PLC | 0.45% | |
| 42 | RGNX Regenxbio | 0.43% | |
| 43 | BWAY Brainsway ADR Representing Ltd | 0.42% | |
| 44 | BNTC Benitec Biopharma Inc | 0.42% | |
| 45 | RLMD Relmada Therapeutics Inc | 0.4% | |
| 46 | NPCE Neuropace | 0.39% | |
| 47 | CLPT Clearpoint Neuro Inc | 0.38% | |
| 48 | 2190 Zylox-Tonbridge Medical Tech H | 0.36% | |
| 49 | 4592 Sanbio Ltd | 0.34% | |
| 50 | 2172 Microport Neurotech Corp | 0.33% | |
| 51 | 9996 Peijia Medical Ltd | 0.31% | |
| 52 | VNDA Vanda Pharmaceuticals Inc | 0.3% | |
| 53 | NWRN Newron Pharmaceuticals | 0.28% | |
| 54 | AVXL Anavex Life Sciences Corp | 0.26% | |
| 55 | SANN Santhera N AG | 0.25% | |
| 56 | IKT Inhibikase Therapeutics | 0.24% | |
| 57 | TNXP Tonix Pharmaceuticals Holding | 0.22% | |
| 58 | ALEC Alector | 0.2% | |
| 59 | ABOS Acumen Pharmaceuticals Inc | 0.2% | |
| 60 | LRMR Larimar Therapeutics | 0.2% | |
| 61 | ACIU Ac Immune SA | 0.19% | |
| 62 | PEPG Pepgen | 0.19% | |
| 63 | VYGR Voyager Therapeutics | 0.18% | |
| 64 | TRDA Entrada Therapeutics | 0.16% | |
| 65 | 317450 Myung in Pharm Ltd | 0.12% | |
| 66 | NMRA Neumora Therapeutics Inc | 0.1% | |
| 67 | MPLT Maplight Therapeutics | 0.1% | |
| 68 | CGTX Cognition Therapeutics Inc | 0.08% |
Issuer file 1 day old on 2026-09-04, against a median of 1 across the funds with a page. Every one of the 68 positions with its weight is in the fund's JSON file. See which other ETFs hold PRAX, and at what weight.
What does IBRN share with other funds?
The fund nearest to IBRN is XBI: the two hold 14.6% of their weight in common, in the 22 companies both own, and 56.0% of IBRN itself is also held there. IBRN barely overlaps any covered fund.
| Fund | Overlap by weight | Of IBRN held there | Of that fund in IBRN | Companies in both | Overlap bar |
|---|---|---|---|---|---|
| XBI | 14.6% | 56.0% | 14.7% | 22 | |
| PBE | 14.5% | 18.7% | 16.3% | 5 | |
| IBB | 13.0% | 70.2% | 13.0% | 33 | |
| PSCH | 11.8% | 18.4% | 11.8% | 6 | |
| IBBQ | 10.8% | 69.5% | 10.8% | 32 | |
| BMED | 9.4% | 24.9% | 9.6% | 6 | |
| PTH | 9.4% | 17.7% | 9.8% | 5 | |
| XPH | 8.5% | 12.9% | 9.7% | 7 | |
| RFG | 4.4% | 9.7% | 4.4% | 3 | |
| IHE | 3.8% | 11.4% | 3.8% | 5 | |
| IWO | 3.8% | 63.4% | 3.9% | 36 | |
| QQQJ | 3.8% | 12.4% | 3.8% | 3 |
From each issuer's latest file. Check IBRN against any fund in the ETF overlap calculator · how overlap is measured.
What adds something different to IBRN?
VDE shares 0% of weight with IBRN and its weekly returns correlate with it at 0.14 over three years. The table lists the covered funds with the least in common with IBRN, least shared weight first and, among equals, lowest correlation.
| Fund | Name | Overlap by weight | Correlation, 3y | Companies in both |
|---|---|---|---|---|
| VDE | Vanguard Energy ETF | 0.0% | 0.14 | 0 |
| SPMO | Invesco S&P 500 Momentum ETF | 0.0% | 0.49 | 0 |
| MGK | Vanguard Morningstar Mega Cap Growth ETF | 0.0% | 0.53 | 0 |
| VYMI | Vanguard International High Dividend Yield ETF | 0.0% | 0.53 | 0 |
| XLG | Invesco S&P 500 Top 50 ETF | 0.0% | 0.55 | 0 |
| VPL | Vanguard FTSE Pacific ETF | 0.0% | 0.56 | 2 |
| MGV | Vanguard Morningstar Mega Cap Value ETF | 0.0% | 0.60 | 0 |
| MGC | Vanguard Morningstar Mega Cap ETF | 0.0% | 0.60 | 0 |
Cost, returns and risk
| Expense ratio | 0.47% |
|---|---|
| Dividend yield | 0.82% |
| Total return, 1 year | 52.3% |
| Total return, 3 years cumulative | 75.7% |
| Total return, 5 years cumulative | n/a |
| Volatility, annualised | 26.1% |
| Worst fall, 3 years | -31.4% |
| Beta against SPY, 3 years of weekly returns | 1.13 |
| Weight in the ten largest positions | 45.1% |
| Largest single position | 5.2% |
Expense ratio, yield and assets are reference data; every other figure is computed here from weekly closes.
How it moves with the market
| Against | Correlation, 3 years | Covariance, annualised, in percent squared |
|---|---|---|
| SPY | 0.63loosely linked | 236 |
| QQQ | 0.55loosely linked | 283 |
Weekly total returns. What the bands mean · why the covariance is printed.
Year by year
| Year | Total return |
|---|---|
| 2026 | 20.9% |
| 2025 | 28.5% |
| 2024 | -2.8% |
| 2023 | 0.9% |
One year
Where to go next
- IDNA, iShares Genomics Immunology and Healthcare ETF
- IHE, iShares U.S. Pharmaceuticals ETF
- IHF, iShares U.S. Healthcare Providers ETF
- IHI, iShares U.S. Medical Devices ETF
- Run a portfolio x-ray to see what IBRN carries once you look through it
- Compare IBRN against any other fund in the builder
Holdings from the issuer file published 2026-09-03. Prices through 2026-09-04. How every figure here is produced. Measurements, not investment advice.
