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XBI holdings and overlap
Last close, 2026-09-04
$163.81 -0.35%
52-week range 93 to 170
Largest position
MRNA
2.98% of the fund, Moderna Inc
Positions
148
15.6% in the ten largest
Cost per year
0.35%
$35 a year on $10,000
Assets
$11.4B
under management
Return, 3 years
+109.6%
cumulative, total return
Worst fall
-29.3%
peak to trough, 3 years, weekly closes
What does XBI hold, as of its issuer file of 2026-09-03?
XBI holds 148 positions as of the issuer file dated 2026-09-03. The three largest are Moderna Inc at 2.98%, Twist Bioscience Corp at 1.75% and Halozyme Therapeutics Inc at 1.45%.
| Rank | Company | Weight | Weight bar |
|---|---|---|---|
| 1 | MRNA Moderna Inc | 2.98% | |
| 2 | TWST Twist Bioscience Corp | 1.75% | |
| 3 | HALO Halozyme Therapeutics Inc | 1.45% | |
| 4 | NTRA Natera Inc | 1.4% | |
| 5 | KYMR Kymera Therapeutics Inc | 1.38% | |
| 6 | PRAX Praxis Precision Medicines I | 1.36% | |
| 7 | RVMD Revolution Medicines Inc | 1.35% | |
| 8 | TVTX Travere Therapeutics Inc | 1.31% | |
| 9 | ORKA Oruka Therapeutics Inc | 1.31% | |
| 10 | DNTH Dianthus Therapeutics Inc | 1.3% | |
| 11 | PTGX Protagonist Therapeutics Inc | 1.3% | |
| 12 | REGN Regeneron Pharmaceuticals | 1.29% | |
| 13 | INSM Insmed Inc | 1.27% | |
| 14 | CGON CG Oncology Inc | 1.25% | |
| 15 | PCVX Vaxcyte Inc | 1.24% | |
| 16 | AMGN Amgen Inc | 1.21% | |
| 17 | SMMT Summit Therapeutics Inc | 1.18% | |
| 18 | VRTX Vertex Pharmaceuticals Inc | 1.18% | |
| 19 | IOVA Iovance Biotherapeutics Inc | 1.17% | |
| 20 | SRRK Scholar Rock Holding Corp | 1.17% | |
| 21 | GILD Gilead Sciences Inc | 1.15% | |
| 22 | VKTX Viking Therapeutics Inc | 1.13% | |
| 23 | RYTM Rhythm Pharmaceuticals Inc | 1.13% | |
| 24 | ARWR Arrowhead Pharmaceuticals in | 1.13% | |
| 25 | TGTX TG Therapeutics Inc | 1.12% | |
| 26 | ERAS Erasca Inc | 1.12% | |
| 27 | INCY Incyte Corp | 1.12% | |
| 28 | ROIV Roivant Sciences Ltd | 1.12% | |
| 29 | RLAY Relay Therapeutics Inc | 1.11% | |
| 30 | SLS Sellas Life Sciences Group I | 1.1% | |
| 31 | KRYS Krystal Biotech Inc | 1.1% | |
| 32 | BMRN Biomarin Pharmaceutical Inc | 1.09% | |
| 33 | SYRE Spyre Therapeutics Inc | 1.07% | |
| 34 | ABBV Abbvie Inc | 1.07% | |
| 35 | BIIB Biogen Inc | 1.07% | |
| 36 | GRAL Grail Inc | 1.06% | |
| 37 | MDGL Madrigal Pharmaceuticals Inc | 1.06% | |
| 38 | CRSP Crispr Therapeutics AG | 1.05% | |
| 39 | EXEL Exelixis Inc | 1.04% | |
| 40 | BBIO Bridgebio Pharma Inc | 1.03% | |
| 41 | COGT Cogent Biosciences Inc | 1.03% | |
| 42 | ACAD Acadia Pharmaceuticals Inc | 1.03% | |
| 43 | CYTK Cytokinetics Inc | 1.02% | |
| 44 | CELC Celcuity Inc | 1.01% | |
| 45 | QURE Uniqure NV | 1.0% | |
| 46 | MIRM Mirum Pharmaceuticals Inc | 0.99% | |
| 47 | ALKS Alkermes PLC | 0.99% | |
| 48 | DYN Dyne Therapeutics Inc | 0.96% | |
| 49 | SRPT Sarepta Therapeutics Inc | 0.95% | |
| 50 | IBRX Immunitybio Inc | 0.95% | |
| 51 | IMVT Immunovant Inc | 0.93% | |
| 52 | BEAM Beam Therapeutics Inc | 0.92% | |
| 53 | NBIX Neurocrine Biosciences Inc | 0.91% | |
| 54 | PTCT PTC Therapeutics Inc | 0.9% | |
| 55 | BCRX Biocryst Pharmaceuticals Inc | 0.9% | |
| 56 | VERA Vera Therapeutics Inc | 0.86% | |
| 57 | IDYA Ideaya Biosciences Inc | 0.86% | |
| 58 | ALNY Alnylam Pharmaceuticals Inc | 0.84% | |
| 59 | VRDN Viridian Therapeutics Inc | 0.83% | |
| 60 | UTHR United Therapeutics Corp | 0.83% | |
| 61 | IMNM Immunome Inc | 0.75% | |
| 62 | PURR Hyperliquid Strategies | 0.75% | |
| 63 | CLDX Celldex Therapeutics Inc | 0.74% | |
| 64 | MLYS Mineralys Therapeutics Inc | 0.74% | |
| 65 | DNLI Denali Therapeutics Inc | 0.73% | |
| 66 | IONS Ionis Pharmaceuticals Inc | 0.73% | |
| 67 | RCUS Arcus Biosciences Inc | 0.72% | |
| 68 | NVAX Novavax Inc | 0.72% | |
| 69 | RXRX Recursion Pharmaceuticals A | 0.7% | |
| 70 | IRON Disc Medicine Inc | 0.7% | |
| 71 | ADMA Adma Biologics Inc | 0.69% | |
| 72 | NTLA Intellia Therapeutics Inc | 0.68% | |
| 73 | SNDX Syndax Pharmaceuticals Inc | 0.68% | |
| 74 | ARQT Arcutis Biotherapeutics Inc | 0.64% | |
| 75 | VCYT Veracyte Inc | 0.62% | |
| 76 | AGIO Agios Pharmaceuticals Inc | 0.61% | |
| 77 | TNGX Tango Therapeutics Inc | 0.61% | |
| 78 | PVLA Palvella Therapeutics Inc | 0.59% | |
| 79 | NRIX Nurix Therapeutics Inc | 0.58% | |
| 80 | BHVN Biohaven Ltd | 0.56% | |
| 81 | CDNA Caredx Inc | 0.53% | |
| 82 | VIR Vir Biotechnology Inc | 0.53% | |
| 83 | KOD Kodiak Sciences Inc | 0.5% | |
| 84 | RARE Ultragenyx Pharmaceutical in | 0.5% | |
| 85 | CGEM Cullinan Therapeutics Inc | 0.49% | |
| 86 | XNCR Xencor Inc | 0.48% | |
| 87 | PGEN Precigen Inc | 0.47% | |
| 88 | INBX Inhibrx Biosciences Inc | 0.46% | |
| 89 | VCEL Vericel Corp | 0.45% | |
| 90 | STOK Stoke Therapeutics Inc | 0.44% | |
| 91 | ABSI Absci Corp | 0.42% | |
| 92 | ANAB Anaptysbio Inc | 0.42% | |
| 93 | ZBIO Zenas Biopharma Inc | 0.41% | |
| 94 | CRVS Corvus Pharmaceuticals Inc | 0.4% | |
| 95 | VOR Vor Biopharma Inc | 0.4% | |
| 96 | REPL Replimune Group Inc | 0.39% | |
| 97 | ORIC Oric Pharmaceuticals Inc | 0.39% | |
| 98 | KURA Kura Oncology Inc | 0.38% | |
| 99 | TRAX First Tracks Biotherapeutics | 0.37% | |
| 100 | AVTX Avalo Therapeutics Inc | 0.36% |
Issuer file 1 day old on 2026-09-04, against a median of 1 across the funds with a page. Every one of the 148 positions with its weight is in the fund's JSON file. See which other ETFs hold MRNA, and at what weight.
What does XBI share with other funds?
The fund nearest to XBI is IBBQ: the two hold 41.4% of their weight in common, in the 115 companies both own, and 83.7% of XBI itself is also held there. No covered fund holds more than that in common with XBI; it duplicates nothing here closely.
| Fund | Overlap by weight | Of XBI held there | Of that fund in XBI | Companies in both | Overlap bar |
|---|---|---|---|---|---|
| IBBQ | 41.4% | 83.7% | 73.7% | 115 | |
| IBB | 41.2% | 86.3% | 75.8% | 120 | |
| PBE | 24.9% | 25.4% | 79.4% | 24 | |
| PTH | 24.6% | 24.7% | 47.1% | 23 | |
| BMED | 20.4% | 24.8% | 39.2% | 22 | |
| IDNA | 19.9% | 20.2% | 55.4% | 24 | |
| IBRN | 14.6% | 14.7% | 56.0% | 22 | |
| IWO | 13.8% | 61.9% | 14.0% | 99 | |
| VHT | 13.4% | 96.0% | 22.4% | 133 | |
| VTWG | 13.3% | 61.9% | 13.3% | 99 | |
| IYH | 12.1% | 28.7% | 23.4% | 24 | |
| RSPH | 11.1% | 11.1% | 17.0% | 8 |
From each issuer's latest file. Check XBI against any fund in the ETF overlap calculator · how overlap is measured.
What adds something different to XBI?
VDE shares 0% of weight with XBI and its weekly returns correlate with it at 0.08 over three years. The table lists the covered funds with the least in common with XBI, least shared weight first and, among equals, lowest correlation.
| Fund | Name | Overlap by weight | Correlation, 3y | Companies in both |
|---|---|---|---|---|
| VDE | Vanguard Energy ETF | 0.0% | 0.08 | 0 |
| VPU | Vanguard Utilities ETF | 0.0% | 0.24 | 0 |
| VDC | Vanguard Consumer Staples ETF | 0.0% | 0.25 | 0 |
| SPLV | Invesco S&P 500 Low Volatility ETF | 0.0% | 0.35 | 0 |
| VOX | Vanguard Communication Services ETF | 0.0% | 0.48 | 0 |
| VPL | Vanguard FTSE Pacific ETF | 0.0% | 0.54 | 0 |
| VIS | Vanguard Industrials ETF | 0.0% | 0.54 | 0 |
| VCR | Vanguard Consumer Discretionary ETF | 0.0% | 0.55 | 0 |
Cost, returns and risk
| Expense ratio | 0.35% |
|---|---|
| Dividend yield | 0.35% |
| Total return, 1 year | 72.4% |
| Total return, 3 years cumulative | 109.6% |
| Total return, 5 years cumulative | 25.2% |
| Volatility, annualised | 27.6% |
| Worst fall, 3 years | -29.3% |
| Beta against SPY, 3 years of weekly returns | 1.08 |
| Weight in the ten largest positions | 15.6% |
| Largest single position | 3.0% |
| Assets under management | $11.4B |
Expense ratio, yield and assets are reference data; every other figure is computed here from weekly closes.
How it moves with the market
| Against | Correlation, 3 years | Covariance, annualised, in percent squared |
|---|---|---|
| SPY | 0.57loosely linked | 226 |
| QQQ | 0.50loosely linked | 272 |
Weekly total returns. What the bands mean · why the covariance is printed.
Year by year
| Year | Total return |
|---|---|
| 2026 | 34.5% |
| 2025 | 35.9% |
| 2024 | 1.0% |
| 2023 | 7.6% |
| 2022 | -25.9% |
One year
XBI 175
SPY 118
2025-09-122026-09-04
Where to go next
- XHE, State Street SPDR S&P Health Care Equipment ETF
- XHS, State Street SPDR S&P Health Care Services ETF
- XLV, Health Care Select Sector SPDR Fund
- XPH, State Street SPDR S&P Pharmaceuticals ETF
- Run a portfolio x-ray to see what XBI carries once you look through it
- Compare XBI against any other fund in the builder
Holdings from the issuer file published 2026-09-03. Prices through 2026-09-04. How every figure here is produced. Measurements, not investment advice.
