Which ETFs hold Vertex Pharmaceuticals (VRTX)?

Name: US ETFs holding Vertex Pharmaceuticals (VRTX), with the weight and file date of each
Creator: TickerInside
License: https://creativecommons.org/licenses/by/4.0/

366 US stock ETFs hold Vertex Pharmaceuticals (VRTX). BBH gives VRTX the largest weight, 9.10% (SEC filing for the period ended 2026-06-30).

Edited by VoidLab Data through 2026-10-13 Last revised 2026-10-13

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VRTXVertex PharmaceuticalsBiotechnology, $123B market cap, P/E 28, beta 0.56, held by 366 US stock ETFs

Last close, 2026-10-12

$507.00 -0.60%

52-week range 407 to 558

Stock ETFs holding it

366

122 in issuer files, 244 in SEC filings; 31 other ETFs listed apart

Largest weight

BBH

9.10% of that ETF, SEC filing for the period ended 2026-06-30

1 year

+21.6%

total return

3 years

+40.1%

worst fall -29.1%, volatility 30.5%

5 years

+176.3%

cumulative

No covered fund makes VRTX its largest position; the highest it ranks is #2, in GNMX. The median weight across the 366 holders is 0.28%: 4 of them carry it above 5% and 302 keep it under 1%. Of the 311 covered funds with 500 or more positions, 107 hold VRTX, at weights from under 0.01% to 0.73%.

Over three years VRTX returned 40.1%, with a worst fall of 29.1% and annualised volatility of 30.5%; its beta against SPY over the same weeks is 0.56. Its best calendar year in the data is 2023 at +40.9% and its worst 2024 at -1.0%.

Is VRTX in VOO, SPY, IVV, QQQ, VTI, SCHD, XLV, VHT or IBB?

VRTX is in 8 of these 9 funds; IBB gives it the most weight, 7.61% (iShares file of 2026-10-12), and SCHD does not hold it.

ETF	Name	Weight	Rank in the ETF	Holdings dated
VOO	Vanguard S&P 500 ETF	0.21%	#84 of 503	Vanguard file, 2026-08-31
SPY	SPDR S&P 500 ETF Trust	0.19%	#88 of 504	SPDR file, 2026-10-12
IVV	iShares Core S&P 500 ETF	0.19%	#88 of 504	iShares file, 2026-10-12
QQQ	Invesco QQQ Trust	0.53%	#40 of 101	Invesco file, 2026-10-12
VTI	Vanguard Total Stock Market ETF	0.19%	#84 of 3458	Vanguard file, 2026-08-31
SCHD	Schwab US Dividend Equity ETF	not held	99 positions	SEC filing, 2026-05-31
XLV	Health Care Select Sector SPDR Fund	2.06%	#13 of 62	SPDR file, 2026-10-12
VHT	Vanguard Health Care ETF	1.92%	#11 of 411	Vanguard file, 2026-08-31
IBB	iShares Biotechnology ETF	7.61%	#3 of 237	iShares file, 2026-10-12

Which ETFs hold VRTX in their issuer files, and at what weight?

122 funds report VRTX in their own issuer files, dated 2026-08-31 to 2026-10-13; IBBQ gives it the most weight, 7.66%.

Rank	ETF	Name	Weight	Issuer file
1	IBBQ	Invesco Nasdaq Biotechnology ETF	7.66%	2026-10-12
2	IBB	iShares Biotechnology ETF	7.61%	2026-10-12
3	PBE	Invesco Biotechnology & Genome ETF	4.69%	2026-10-12
4	GNOM	Global X Genomics & Biotechnology ETF	3.33%	2026-10-12
5	BMED	iShares Health Innovation Active ETF	3.27%	2026-10-12
6	IDNA	iShares Genomics Immunology and Healthcare ETF	3.21%	2026-10-12
7	QNXT	iShares Nasdaq-100 ex Top 30 ETF	2.41%	2026-10-12
8	TECB	iShares U.S. Tech Breakthrough Multisector ETF	2.40%	2026-10-12
9	XLV	Health Care Select Sector SPDR Fund	2.06%	2026-10-12
10	IYH	iShares U.S. Healthcare ETF	2.00%	2026-10-12
11	VHT	Vanguard Health Care ETF	1.92%	2026-08-31
12	IXJ	iShares Global Healthcare ETF	1.57%	2026-10-12
13	RSPH	Invesco S&P 500 Equal Weight Health Care ETF	1.55%	2026-10-12
14	SDG	iShares MSCI Global Sustainable Development Goals ETF	1.50%	2026-10-12
15	XBI	SPDR S&P Biotech ETF	1.46%	2026-10-12
16	ESMV	iShares ESG Optimized MSCI USA Min Vol Factor ETF	1.38%	2026-10-12
17	USMV	iShares MSCI USA Min Vol Factor ETF	1.34%	2026-10-12
18	QEW	Invesco QQQ Equal Weight ETF	0.93%	2026-10-12
19	XOEF	iShares S&P 500 ex S&P 100 ETF	0.74%	2026-10-12
20	QUS	State Street SPDR MSCI USA StrategicFactors℠ ETF	0.73%	2026-10-12
21	OMFL	Invesco Russell 1000 Dynamic Multifactor ETF	0.67%	2026-10-12
22	BDVL	iShares Disciplined Volatility Equity Active ETF	0.65%	2026-10-12
23	MGK	Vanguard Morningstar Mega Cap Growth ETF	0.64%	2026-08-31
24	XT	iShares Future Exponential Technologies ETF	0.62%	2026-10-12
25	BDYN	iShares Dynamic Equity Active ETF	0.55%	2026-10-12
26	QRMI	Global X Nasdaq 100 Risk Managed Income ETF	0.55%	2026-10-12
27	VUSG	Vanguard Wellington U.S. Growth Active ETF	0.55%	2026-10-13
28	IQQ	iShares Nasdaq 100 ETF	0.54%	2026-10-12
29	QYLG	Global X Nasdaq 100 Covered Call & Growth ETF	0.54%	2026-10-12
30	ACWV	iShares MSCI Global Min Vol Factor ETF	0.54%	2026-10-12
31	QNDX	State Street SPDR Portfolio Nasdaq 100 ETF	0.54%	2026-10-12
32	QQQM	Invesco Nasdaq 100 ETF	0.53%	2026-10-12
33	QQQ	Invesco QQQ Trust	0.53%	2026-10-12
34	QTR	Global X Nasdaq 100 Tail Risk ETF	0.53%	2026-10-12
35	QYLD	Global X Nasdaq 100 Covered Call ETF	0.53%	2026-10-13
36	QCLR	Global X Nasdaq 100 Collar 95-110 ETF	0.52%	2026-10-08
37	USXF	iShares ESG Advanced MSCI USA ETF	0.51%	2026-10-12
38	QQMG	Invesco ESG NASDAQ 100 ETF	0.48%	2026-10-12
39	IWX	iShares Russell Top 200 Value ETF	0.47%	2026-10-12
40	VOOV	Vanguard S&P 500 Value ETF	0.46%	2026-08-31
41	SPYV	SPDR Portfolio S&P 500 Value ETF	0.43%	2026-10-12
42	IVE	iShares S&P 500 Value ETF	0.43%	2026-10-12
43	QUAL	iShares MSCI USA Quality Factor ETF	0.43%	2026-10-12
44	SHE	State Street SPDR MSCI USA Gender Diversity ETF	0.42%	2026-10-12
45	QWLD	State Street SPDR MSCI World StrategicFactors℠ ETF	0.41%	2026-10-12
46	IUSV	iShares Core S&P U.S. Value ETF	0.41%	2026-10-12
47	QQA	Invesco QQQ Income Advantage ETF	0.40%	2026-10-12
48	VUG	Vanguard Growth ETF	0.39%	2026-08-31
49	SUSA	iShares ESG Optimized MSCI USA ETF	0.37%	2026-10-12
50	VONV	Vanguard Russell 1000 Value ETF	0.37%	2026-08-31
51	SUSL	iShares ESG MSCI USA Leaders ETF	0.36%	2026-10-12
52	AQLT	iShares MSCI Global Quality Factor ETF	0.36%	2026-10-12
53	DSI	iShares ESG MSCI KLD 400 ETF	0.35%	2026-10-12
54	IWD	iShares Russell 1000 Value ETF	0.35%	2026-10-12
55	EGLE	Global X S&P 500 U.S. Revenue Leaders ETF	0.29%	2026-10-12
56	ILCV	iShares Morningstar Value ETF	0.26%	2026-10-12
57	MGC	Vanguard Morningstar Mega Cap ETF	0.25%	2026-08-31
58	ESGU	iShares ESG Aware MSCI USA ETF	0.24%	2026-10-12
59	PABU	iShares Paris-Aligned Climate Optimized MSCI USA ETF	0.24%	2026-10-12
60	QVML	Invesco S&P 500 QVM Multi-factor ETF	0.24%	2026-10-12
61	USCL	iShares Climate Conscious & Transition MSCI USA ETF	0.23%	2026-10-12
62	TOPC	iShares S&P 500 3% Capped ETF	0.23%	2026-10-12
63	LCTU	iShares U.S. Carbon Transition Readiness Aware Active ETF	0.23%	2026-10-12
64	XVV	iShares ESG Select Screened S&P 500 ETF	0.23%	2026-10-12
65	SPIN	State Street US Equity Premium Income ETF	0.23%	2026-10-12
66	EGUS	iShares ESG Aware MSCI USA Growth ETF	0.22%	2026-10-12
67	IWL	iShares Russell Top 200 ETF	0.22%	2026-10-12
68	KLMN	Invesco MSCI North America Climate ETF	0.21%	2026-10-12
69	VV	Vanguard Morningstar Large-Cap ETF	0.21%	2026-08-31
70	ESGV	Vanguard ESG U.S. Stock ETF	0.21%	2026-10-13
71	SIZE	iShares MSCI USA Size Factor ETF	0.21%	2026-10-12
72	VOO	Vanguard S&P 500 ETF	0.21%	2026-08-31
73	XRMI	Global X S&P 500 Risk Managed Income ETF	0.20%	2026-10-12
74	SPYX	State Street SPDR S&P 500 Fossil Fuel Reserves Free ETF	0.20%	2026-10-12
75	VONE	Vanguard Russell 1000 ETF	0.20%	2026-08-31
76	IVVW	iShares S&P 500 BuyWrite ETF	0.20%	2026-10-12
77	RSP	Invesco S&P 500 Equal Weight ETF	0.20%	2026-10-12
78	PBUS	Invesco MSCI USA ETF	0.19%	2026-10-12
79	ILCB	iShares Morningstar U.S. Equity ETF	0.19%	2026-10-01
80	SPY	SPDR S&P 500 ETF Trust	0.19%	2026-10-12
81	MLRG	iShares MSCI USA ETF	0.19%	2026-10-12
82	SPYM	State Street SPDR Portfolio S&P 500 ETF	0.19%	2026-10-12
83	IVV	iShares Core S&P 500 ETF	0.19%	2026-10-12
84	GXLC	Global X U.S. 500 ETF	0.19%	2026-10-12
85	XCLR	Global X S&P 500 Collar 95-110 ETF	0.19%	2026-10-08
86	XTR	Global X S&P 500 Tail Risk ETF	0.19%	2026-10-12
87	XYLD	Global X S&P 500 Covered Call ETF	0.19%	2026-10-13
88	XYLG	Global X S&P 500 Covered Call & Growth ETF	0.19%	2026-10-12
89	VTI	Vanguard Total Stock Market ETF	0.19%	2026-08-31
90	VTHR	Vanguard Russell 3000 ETF	0.19%	2026-08-31
91	EUSA	iShares MSCI USA Equal Weighted ETF	0.19%	2026-10-12
92	VFMF	Vanguard U.S. Multifactor ETF	0.18%	2026-10-13
93	ONOF	Global X Adaptive U.S. Risk Management ETF	0.18%	2026-10-12
94	IWB	iShares Russell 1000 ETF	0.18%	2026-10-12
95	IYY	iShares Dow Jones U.S. ETF	0.18%	2026-10-12
96	SPTM	State Street SPDR Portfolio S&P 1500 Composite Stock Market ETF	0.18%	2026-10-12
97	ENHU	iShares Enhanced Large Cap Core Active ETF	0.17%	2026-10-12
98	IWV	iShares Russell 3000 ETF	0.17%	2026-10-12
99	ITOT	iShares Core S&P Total U.S. Stock Market ETF	0.17%	2026-10-12
100	TOK	iShares MSCI Kokusai ETF	0.15%	2026-10-12
101	KLMT	Invesco MSCI Global Climate 500 ETF	0.15%	2026-10-12
102	EVUS	iShares ESG Aware MSCI USA Value ETF	0.15%	2026-10-12
103	RSPA	Invesco S&P 500 Equal Weight Income Advantage ETF	0.15%	2026-10-12
104	URTH	iShares MSCI World ETF	0.14%	2026-10-12
105	IUS	Invesco RAFI Strategic US ETF	0.14%	2026-10-12
106	PRF	Invesco RAFI US 1000 ETF	0.14%	2026-10-12
107	INRO	iShares U.S. Industry Rotation Active ETF	0.14%	2026-10-12
108	VFMO	Vanguard U.S. Momentum Factor ETF	0.13%	2026-10-13
109	ACWI	iShares MSCI ACWI ETF	0.12%	2026-10-12
110	MMTM	State Street SPDR S&P 1500 Momentum Tilt ETF	0.12%	2026-10-12
111	NZAC	State Street SPDR MSCI ACWI Climate Paris Aligned ETF	0.12%	2026-10-12
112	VT	Vanguard Total World Stock ETF	0.12%	2026-08-31
113	ILCG	iShares Morningstar Growth ETF	0.11%	2026-10-12
114	ONEO	State Street SPDR Russell 1000 Momentum Focus ETF	0.11%	2026-10-12
115	CRBN	iShares Low Carbon Optimized MSCI ACWI ETF	0.11%	2026-10-12
116	VLU	State Street SPDR S&P 1500 Value Tilt ETF	0.10%	2026-10-12
117	KOMP	State Street SPDR S&P Kensho New Economies Composite ETF	0.09%	2026-10-12
118	EQAL	Invesco Russell 1000 Equal Weight ETF	0.09%	2026-10-12
119	BFLX	iShares Flexible Equity Active ETF	0.09%	2026-10-12
120	RWL	Invesco S&P 500 Revenue ETF	0.06%	2026-10-12
121	SPGM	State Street SPDR Portfolio MSCI Global Stock Market ETF	0.06%	2026-10-12
122	DYNF	iShares U.S. Equity Factor Rotation Active ETF	0.05%	2026-10-12

Each of these 122 rows is dated by its issuer's own file, published on the issuer's schedule; the same 122 rows, in the same order, are in the JSON file for VRTX and in the holders index. Look VRTX up with an amount to see what a position in each ETF holds of it in dollars.

Use this data

JSONhttps://tickerinside.com/api/v1/sec/vrtx.json

CSVhttps://tickerinside.com/api/v1/sec/vrtx.csv

Sheets=IMPORTDATA("https://tickerinside.com/api/v1/sec/vrtx.csv")If your sheet uses a decimal comma: =IMPORTDATA("https://tickerinside.com/api/v1/sec/vrtx.csv"; ","; "en_US")

curlcurl -s https://tickerinside.com/api/v1/sec/vrtx.json

API reference · spreadsheet guide Add TickerInside to Claude to ask about VRTX with this data

Which ETFs hold VRTX in their latest SEC filing?

244 funds hold VRTX in their latest Form N-PORT filing with the SEC, for periods ended 2026-05-29 to 2026-07-31; BBH gives it the most weight, 9.10%.

ETF	Name	Weight	Period of the filing
BBH	VanEck Biotech ETF	9.10%	2026-06-30
GNMX	Corgi Genomics & Precision Medicine ETF	6.71%	2026-06-30
LSGR	Natixis Loomis Sayles Focused Growth ETF	4.78%	2026-06-30
FTXH	First Trust Nasdaq Pharmaceuticals ETF	3.41%	2026-06-30
FBT	First Trust NYSE Arca Biotechnology Index Fund	3.07%	2026-06-30
QFRD	Pacer S&P 500 Quality FCF R&D Leaders ETF	2.98%	2026-07-31
HRTS	Tema Heart & Health ETF	2.93%	2026-05-31
PBPH	Portfolio Building Block World Pharma and Biotech Index ETF	2.82%	2026-07-31
HELX	Franklin Genomic Advancements ETF	2.75%	2026-06-30
KONG	Formidable Fortress ETF	2.66%	2026-06-30
EXEQ	Wedbush ReturnOnLeadership(R) U.S. Large-Cap ETF	2.49%	2026-07-31
SXQG	ETC 6 Meridian Quality Growth ETF	2.49%	2026-05-31
LRGE	ClearBridge Large Cap Growth Select ETF	2.28%	2026-06-30
CGGG	Capital Group U.S. Large Growth ETF	2.25%	2026-05-31
TRUH	VanEck Healthcare TruSector ETF	2.21%	2026-06-30
QQEW	First Trust Nasdaq-100 Select Equal Weight ETF	2.18%	2026-06-30
GPT	Intelligent Alpha Atlas ETF	2.09%	2026-06-30
QQXT	First Trust NASDAQ-100 Ex-Technology Sector Index Fund	2.07%	2026-06-30
RND	First Trust Bloomberg R&D Leaders ETF	2.06%	2026-06-30
ASLV	Allspring Special Large Value ETF	2.05%	2026-07-31
NBFR	Innovator Nasdaq-100 Managed 10 Buffer ETF	1.97%	2026-07-31
DRUP	GraniteShares Nasdaq Select Disruptors ETF	1.94%	2026-06-30
HTEC	ROBO Global Healthcare Technology and Innovation ETF	1.91%	2026-07-31
FFLS	The Future Fund Long/Short ETF	1.84%	2026-05-31
FHLC	Fidelity MSCI Health Care Index ETF	1.76%	2026-07-31
QQQG	Pacer Nasdaq 100 Top 50 Cash Cows Growth Leaders ETF	1.64%	2026-07-31
REGS	Columbia Large Cap Growth ETF	1.58%	2026-06-30
CGUS	Capital Group Core Equity ETF	1.58%	2026-05-31
CGGR	Capital Group Growth ETF	1.56%	2026-05-31
NULG	Nuveen ESG Large-Cap Growth ETF	1.50%	2026-07-31
TOLL	Tema Durable Quality ETF	1.49%	2026-05-31
GDOC	Goldman Sachs Future Health Care Equity ETF	1.48%	2026-05-31
BBP	Virtus Biotech Etf	1.48%	2026-07-31
JEPI	JPMorgan Equity Premium Income ETF	1.46%	2026-06-30
PINK	Simplify Health Care ETF	1.45%	2026-06-30
FFND	One Global ETF	1.45%	2026-05-31
SEIQ	SEI Enhanced U.S. Large Cap Quality Factor ETF	1.36%	2026-06-30
WDNA	WisdomTree BioRevolution Fund	1.34%	2026-06-30
CGVV	Capital Group U.S. Large Value ETF	1.28%	2026-05-31
RILA	Indexperts Gorilla Aggressive Growth ETF	1.26%	2026-07-31
MEDI	Harbor Health Care ETF	1.22%	2026-07-31
CGBL	Capital Group Core Balanced ETF	1.20%	2026-06-30
CGGO	Capital Group Global Growth Equity ETF	1.14%	2026-05-31
AGRW	Allspring LT Large Growth ETF	1.11%	2026-07-31
QQQE	Direxion NASDAQ-100 Equal Weighted Index Shares	1.09%	2026-07-31
SQS	Sapient Quality Select ETF	1.07%	2026-07-31
LST	Leuthold Select Industries ETF	1.03%	2026-06-30
RFFC	ALPS Active Equity Opportunity ETF	0.97%	2026-05-31
LGRO	Level Four Large Cap Growth Active ETF	0.96%	2026-05-31
ENDW	Cambria Endowment Style ETF	0.90%	2026-05-29
HEMI	Hartford Equity Premium Income ETF	0.90%	2026-07-31
PJFG	PGIM Jennison Focused Growth ETF	0.86%	2026-05-29
JDOC	JPMorgan Healthcare Leaders ETF	0.81%	2026-07-31
FXH	First Trust Health Care AlphaDEX Fund	0.81%	2026-07-31
COWG	Pacer US Large Cap Cash Cows Growth Leaders ETF	0.81%	2026-07-31
CGDV	Capital Group Dividend Value ETF	0.80%	2026-05-31
LVDS	JPMorgan Fundamental Data Science Large Value ETF	0.80%	2026-06-30
XIGV	Defiance US 100 Tech Ex Software ETF	0.79%	2026-06-30
JOET	Virtus Terranova U.S. Quality Momentum ETF	0.77%	2026-07-31
MODL	VictoryShares WestEnd US Sector ETF	0.76%	2026-06-30
LRND	NYLIM U.S. Large Cap R&D Leaders ETF	0.69%	2026-07-31
SGLC	SGI U.S. Large Cap Core ETF	0.68%	2026-05-31
LRGC	AB US Large Cap Strategic Equities ETF	0.68%	2026-05-31
AVIE	Avantis Inflation Focused Equity ETF	0.68%	2026-05-31
TNXT	T. Rowe Price Innovation Leaders ETF	0.67%	2026-06-30
QIDX	Indexperts Quality Earnings Focused ETF	0.65%	2026-07-31
GPIQ	Goldman Sachs Nasdaq-100 Premium Income ETF	0.63%	2026-06-30
QGRW	WisdomTree U.S. Quality Growth Fund	0.63%	2026-06-30
TUG	STF Tactical Growth ETF	0.62%	2026-06-30
JEPQ	JPMorgan Nasdaq Equity Premium Income ETF	0.59%	2026-06-30
SEPQ	STF Tactical Growth & Income ETF	0.58%	2026-06-30
CAPE	DoubleLine Shiller Cape U.S. Equities ETF	0.58%	2026-06-30
PTNQ	Pacer Trendpilot 100 ETF	0.55%	2026-07-31
QQQI	NEOS Nasdaq-100(R) High Income ETF	0.55%	2026-06-30
QQQH	NEOS Nasdaq-100(R) Hedged Equity Income ETF	0.55%	2026-06-30
QQWZ	Pacer Cash COWZ 100-Nasdaq 100 Rotator ETF	0.54%	2026-07-31
COPY	Tweedy, Browne Insider + Value ETF	0.53%	2026-05-31
CRTC	Xtrackers US National Critical Technologies ETF	0.53%	2026-05-31
CDEI	Calvert US Large-Cap Diversity, Equity and Inclusion Index ETF	0.53%	2026-06-30
DFUV	Dimensional U.S. Marketwide Value ETF	0.52%	2026-07-31
AFGR	First Trust Multi-Manager Large Growth ETF	0.51%	2026-05-31
QSIX	Pacer Metaurus Nasdaq 100 Dividend Multiplier 600 ETF	0.51%	2026-07-31
WOMN	Impact Shares Women's Empowerment ETF	0.50%	2026-06-30
ACLC	American Century Large Cap Equity ETF	0.50%	2026-05-31
BAMG	Brookstone Growth Stock ETF	0.49%	2026-05-31
RCGE	RockCreek Global Equality ETF	0.48%	2026-07-31
GINN	Goldman Sachs Innovate Equity ETF	0.47%	2026-05-31
ACGR	American Century Large Cap Growth ETF	0.47%	2026-05-31
XQQI	NEOS Boosted Nasdaq-100(R) High Income ETF	0.45%	2026-06-30
BTAL	AGF U.S. Market Neutral Anti-Beta Fund	0.44%	2026-06-30
XCHG	AB US Equity ETF	0.44%	2026-05-31
GGUS	Goldman Sachs MarketBeta(R) Russell 1000 Growth Equity ETF	0.44%	2026-05-31
ESG	FlexShares STOXX US ESG Select Index Fund	0.43%	2026-07-31
TMFC	Motley Fool 100 Index ETF	0.43%	2026-05-31
CGGE	Capital Group Global Equity ETF	0.43%	2026-05-31
TEC	Harbor Transformative Technologies ETF	0.42%	2026-07-31
MNZL	Manzil Russell Halal USA Broad Market ETF	0.42%	2026-07-31
QQH	HCM Defender 100 Index ETF	0.40%	2026-06-30
RGLO	Russell Investments Global Equity ETF	0.40%	2026-06-30
SCHG	Schwab U.S. Large-Cap Growth ETF	0.40%	2026-05-31
SFY	Sofi Select 500 ETF	0.39%	2026-05-31
VPX	Variant Perception Cycle Aware US Equity ETF	0.39%	2026-05-29
JUSA	JPMorgan U.S. Research Enhanced Large Cap ETF	0.39%	2026-06-30
LCDS	JPMorgan Fundamental Data Science Large Core ETF	0.38%	2026-06-30
ROCY	JPMorgan Equity Premium Yield ETF	0.38%	2026-06-30
FTC	First Trust Large Cap Growth AlphaDEX Fund	0.37%	2026-07-31
WINN	Harbor Long-Term Growers ETF	0.37%	2026-07-31
FWD	AB Disruptors ETF	0.37%	2026-05-31
AVSU	Avantis Responsible U.S. Equity ETF	0.37%	2026-05-31
NULC	Nuveen ESG Large-Cap ETF	0.37%	2026-07-31
JOYT	JPMorgan Equity and Options Total Return ETF	0.36%	2026-07-31
PRXG	Praxis Impact Large Cap Growth ETF	0.35%	2026-06-30
IQSU	NYLIM Candriam U.S. Large Cap Equity ETF	0.35%	2026-07-31
HELO	JPMorgan Hedged Equity Laddered Overlay ETF	0.35%	2026-07-31
USSG	Xtrackers MSCI USA Selection Equity ETF	0.33%	2026-05-29
REVS	Columbia Research Enhanced Value ETF	0.33%	2026-07-31
HLAL	Wahed FTSE USA Shariah ETF	0.32%	2026-05-31
AVUQ	Avantis U.S. Quality ETF	0.32%	2026-05-31
ESGG	FlexShares STOXX Global ESG Select Index Fund	0.32%	2026-07-31
SSPY	Stratified LargeCap Index ETF	0.31%	2026-06-30
WRND	NYLIM Global Equity R&D Leaders ETF	0.30%	2026-07-31
SPUS	Sp Funds S&P 500 Sharia Industry Exclusions ETF	0.30%	2026-05-31
DFLV	Dimensional US Large Cap Value ETF	0.30%	2026-07-31
MPLY	Monopoly ETF	0.29%	2026-07-31
QLV	FlexShares US Quality Low Volatility Index Fund	0.29%	2026-07-31
STOX	Horizon Core Equity ETF	0.29%	2026-05-31
SFTY	Horizon Managed Risk ETF	0.29%	2026-05-31
SPXT	ProShares S&P 500 Ex-Technology ETF	0.28%	2026-05-31
JAVA	JPMorgan Active Value ETF	0.28%	2026-06-30
NBCR	Neuberger Core Equity ETF	0.28%	2026-05-31
TGRT	T. Rowe Price Growth ETF	0.26%	2026-06-30
XMAG	Defiance Large Cap ex-Mag 7 ETF	0.26%	2026-05-31
ACVF	American Conservative Values ETF	0.25%	2026-07-31
HQGO	Hartford US Quality Growth ETF	0.25%	2026-07-31
STXG	Strive 1000 Growth ETF	0.25%	2026-06-30
LOPP	Gabelli Love Our Planet & People ETF	0.25%	2026-06-30
ONEQ	Fidelity Nasdaq Composite Index ETF	0.25%	2026-05-31
USNZ	Xtrackers Net Zero Pathway Paris Aligned US Equity ETF	0.24%	2026-05-29
DFVE	DoubleLine Fortune 500 Equal Weight ETF	0.24%	2026-06-30
TVAL	T. Rowe Price Value ETF	0.24%	2026-06-30
PQUS	Pictet AI Enhanced US Equity ETF	0.24%	2026-06-30
AAEQ	Alpha Architect US Equity 2 ETF	0.23%	2026-06-30
CVLC	Calvert US Large-Cap Core Responsible Index ETF	0.23%	2026-06-30
TSPA	T. Rowe Price U.S. Equity Research ETF	0.23%	2026-06-30
MSLC	Morgan Stanley Pathway Large Cap Equity ETF	0.22%	2026-05-31
JSTC	Adasina Social Justice All Cap Global ETF	0.22%	2026-05-31
BFOR	Barrons 400 ETF	0.22%	2026-05-31
AAUA	Alpha Architect US Equity 3 ETF	0.22%	2026-06-30
AAUS	Alpha Architect US Equity ETF	0.22%	2026-06-30
GUSE	Goldman Sachs Enhanced U.S. Equity ETF	0.22%	2026-05-31
USCA	Xtrackers MSCI USA Climate Action Equity ETF	0.21%	2026-05-29
PWS	Pacer WealthShield ETF	0.21%	2026-07-31
FINA	Fidelity MSCI North American Subset Index ETF	0.21%	2026-07-31
GPIX	Goldman Sachs S&P 500 Premium Income ETF	0.21%	2026-06-30
DSPY	Tema S&P 500 Historical Weight ETF Strategy	0.21%	2026-05-31
GSEW	Goldman Sachs Equal Weight U.S. Large Cap Equity ETF	0.21%	2026-05-31
EEE	Cyber Hornet S&P 500 & Ethereum 75/25 Strategy ETF	0.20%	2026-06-30
XXX	Cyber Hornet S&P 500 & XRP 75/25 Strategy ETF	0.20%	2026-06-30
SPXN	ProShares S&P 500 Ex-Financials ETF	0.20%	2026-05-31
RAUS	Racwi US ETF	0.20%	2026-06-30
STXF	Strive 500 ETF	0.20%	2026-06-30
USPX	Franklin U.S. Equity Index ETF	0.20%	2026-06-30
SPYI	NEOS S&P 500(R) High Income ETF	0.20%	2026-06-30
VSLU	Applied Finance Valuation Large Cap ETF	0.19%	2026-06-30
PBP	Invesco S&P 500 BuyWrite ETF	0.19%	2026-07-31
OALC	Oneascent Large Cap Core ETF	0.19%	2026-05-31
BKLC	BNY Mellon US Large Cap Core Equity ETF	0.19%	2026-07-31
PTLC	Pacer Trendpilot US Large Cap ETF	0.19%	2026-07-31
JUST	Goldman Sachs JUST U.S. Large Cap Equity ETF	0.19%	2026-05-31
BBUS	JPMorgan Betabuilders U.S. Equity ETF	0.19%	2026-07-31
FLCG	Federated Hermes MDT Large Cap Growth ETF	0.19%	2026-05-31
ACIO	Aptus Collared Investment Opportunity ETF	0.19%	2026-07-31
VOTE	TCW Transform 500 ETF	0.19%	2026-07-31
FAD	First Trust Multi Cap Growth AlphaDEX Fund	0.19%	2026-07-31
SPYH	NEOS S&P 500(R) Hedged Equity Income ETF	0.18%	2026-06-30
SPXE	ProShares S&P 500 Ex-Energy ETF	0.18%	2026-05-31
ADME	Aptus Drawdown Managed Equity ETF	0.18%	2026-07-31
TOV	JLens 500 Jewish Advocacy U.S. ETF	0.18%	2026-07-31
USEW	Cambria US EW ETF	0.18%	2026-05-29
GSUS	Goldman Sachs MarketBeta U.S. Equity ETF	0.18%	2026-05-31
RWLC	Rayliant NxtGen Multifactor US Equity ETF	0.18%	2026-06-30
WAMA	WisdomTree U.S. Adaptive Moving Average Fund	0.18%	2026-06-30
DFUS	Dimensional U.S. Equity Market ETF	0.18%	2026-07-31
RECS	Columbia Research Enhanced Core ETF	0.18%	2026-07-31
DFSU	Dimensional US Sustainability Core 1 ETF	0.17%	2026-07-31
VOXP	Vox Populi ETF	0.17%	2026-07-31
WCEO	Hypatia Women CEO ETF	0.17%	2026-07-31
QDPL	Pacer Metaurus US Large Cap Dividend Multiplier 400 ETF	0.17%	2026-07-31
ROUS	Hartford Multifactor US Equity ETF	0.17%	2026-07-31
XSPI	NEOS Boosted S&P 500(R) High Income ETF	0.17%	2026-06-30
BKLG	BNY Mellon US Large Cap Equity Growth ETF	0.17%	2026-07-31
OPTZ	Optimize Strategy Index ETF	0.17%	2026-06-30
JQUA	JPMorgan U.S. Quality Factor ETF	0.17%	2026-07-31
SCHX	Schwab U.S. Large-Cap ETF	0.17%	2026-05-31
NTSX	WisdomTree U.S. Efficient Core Fund	0.17%	2026-06-30
GUSA	Goldman Sachs MarketBeta U.S. 1000 Equity ETF	0.16%	2026-05-31
SCHK	Schwab 1000 Index ETF	0.16%	2026-05-31
TILT	FlexShares Morningstar US Market Factor Tilt Index Fund	0.16%	2026-07-31
CFA	VictoryShares US 500 Volatility Wtd ETF	0.16%	2026-06-30
SCHB	Schwab U.S. Broad Market ETF	0.16%	2026-05-31
CFO	VictoryShares US 500 Enhanced Volatility Wtd ETF	0.16%	2026-06-30
LGH	HCM Defender 500 Index ETF	0.15%	2026-06-30
GQI	Natixis Gateway Quality Income ETF	0.15%	2026-06-30
BBB	Cyber Hornet S&P 500 and Bitcoin 75/25 Strategy ETF	0.15%	2026-06-30
PHDG	Invesco S&P 500 Downside Hedged ETF	0.15%	2026-07-31
HCMT	Direxion HCM Tactical Enhanced US ETF	0.15%	2026-07-31
EPS	WisdomTree U.S. LargeCap Fund	0.15%	2026-06-30
AIEQ	Amplify AI Powered Equity ETF	0.15%	2026-06-30
APUE	ActivePassive U.S. Equity ETF	0.14%	2026-05-31
FLCC	Federated Hermes MDT Large Cap Core ETF	0.14%	2026-05-31
AVUS	Avantis U.S. Equity ETF	0.14%	2026-05-31
DFVX	Dimensional US Large Cap Vector ETF	0.14%	2026-07-31
AVLC	Avantis U.S. Large Cap Equity ETF	0.14%	2026-05-31
GDE	WisdomTree Efficient Gold Plus Equity Strategy Fund	0.14%	2026-05-31
TACU	T. Rowe Price Active Core U.S. Equity ETF	0.14%	2026-06-30
DFAU	Dimensional US Core Equity Market ETF	0.13%	2026-07-31
KOKU	Xtrackers MSCI Kokusai Equity ETF	0.13%	2026-05-29
JHML	John Hancock Multifactor Large Cap ETF	0.13%	2026-06-30
NANC	Unusual Whales Subversive Democratic Trading ETF	0.12%	2026-06-30
GSWO	Goldman Sachs ActiveBeta World Equity ETF	0.11%	2026-05-31
LGDX	Intech S&P Large Cap Diversified Alpha ETF	0.11%	2026-07-31
MFUS	PIMCO RAFI Dynamic Multi-Factor U.S. Equity ETF	0.10%	2026-06-30
RAA	SMI 3Fourteen REAL Asset Allocation ETF	0.10%	2026-06-30
DFAL	Dimensional US Large Cap Core Equity Market ETF	0.10%	2026-07-31
DCOR	Dimensional US Core Equity 1 ETF	0.10%	2026-07-31
SPUT	Innovator Equity Premium Income - Daily PutWrite ETF	0.10%	2026-07-31
EQL	ALPS Equal Sector Weight ETF	0.09%	2026-05-31
DFAC	Dimensional U.S. Core Equity 2 ETF	0.09%	2026-07-31
FNDX	Schwab Fundamental U.S. Large Company ETF	0.09%	2026-05-31
FEX	First Trust Large Cap Core AlphaDEX Fund	0.09%	2026-07-31
FNDB	Schwab Fundamental U.S. Broad Market ETF	0.08%	2026-05-31
GSLC	Goldman Sachs ActiveBeta(R) U.S. Large Cap Equity ETF	0.08%	2026-05-31
GEW	Cambria Global EW ETF	0.07%	2026-05-29
GTPE	Goldman Sachs MSCI World Private Equity Return Tracker ETF	0.07%	2026-05-31
QARP	Xtrackers Russell 1000 US Quality at a Reasonable Price ETF	0.07%	2026-05-29
PRXV	Praxis Impact Large Cap Value ETF	0.06%	2026-06-30
GSPY	Gotham Enhanced 500 ETF	0.06%	2026-06-30
MHIP	Milliman Healthcare Inflation Plus ETF	0.05%	2026-06-30
DXUV	Dimensional US Vector Equity ETF	0.04%	2026-07-31
AVTM	Avantis Total Equity Markets ETF	0.03%	2026-05-31
SPXD	Xtrackers S&P 500 Diversified Sector Weight ETF	0.01%	2026-05-31
THEQ	T. Rowe Price Hedged Equity ETF	0.01%	2026-06-30
EBI	Longview Advantage ETF	under 0.01%	2026-05-31
NPFE	NPF Core Equity ETF	under 0.01%	2026-07-31

Each of the 244 dates is the end of the period a holder of VRTX reported in its Form N-PORT filing, and opens that filing on EDGAR, the SEC's public archive. The same rows are under holders_sec_nport in the JSON file for VRTX.

How many ETFs held VRTX each year since 2019?

348 of today's US stock ETFs held VRTX in their SEC reports for the second quarter of 2026, against 117 for the fourth quarter of 2019.

ETFs holding it, Q2 2026

348

in their SEC reports

ETFs holding it, Q4 2019

117

the same ETFs, 2019

Since Q4 2019

+231

ETFs holding it

Largest weight, Q2 2026

BBH

9.10% of the ETF

Quarter	ETFs	Largest weight
Q4 2019	117	IBB 6.69%
Q4 2020	168	BBH 5.22%
Q4 2021	197	BBH 5.35%
Q4 2022	236	IBBQ 7.32%
Q4 2023	283	BBH 10.68%
Q4 2024	277	BBH 10.42%
Q4 2025	305	BBH 9.12%
Q2 2026	348	BBH 9.10%

VRTX in the SEC reports (Form N-PORT) of today's US stock ETFs, Q4 2019 to Q2 2026, every quarter in its file. How these are counted.

Which ETFs have swap, futures or option exposure to VRTX?

Two funds reference VRTX through swaps, futures or options in their latest SEC filing: IINC (written puts 0.90%) and IALT (direction not stated). These figures are notional exposure, in percent of each fund's net assets, not shares held, and none of these funds is counted among the 366 holders of VRTX above.

ETF	Name	Notional exposure, not shares held	Instruments	Period of the filing
IINC	Alki Consolidated Income ETF	Written puts 0.90%	option	2026-06-30
IALT	iShares Systematic Alternatives Active ETF	Direction not stated	swap	2026-07-31

Which other ETFs hold VRTX outright?

22 derivative-based funds, three multi-asset funds, one fixed income fund and five funds read from their sponsors' files hold VRTX outright in SEC filings and sponsors' files dated 2026-05-31 to 2026-10-13; TBXU gives it the most weight, 7.84%. None of them is counted among the 366 US stock ETFs above.

ETF	Name	Kind of ETF	Held outright	Holdings dated
TBXU	Direxion Daily Biotech Top 5 Bull 2X ETF	Derivative-based	7.84%	SEC filing, 2026-07-31
BIB	ProShares Ultra Nasdaq Biotechnology	Derivative-based	4.65%	SEC filing, 2026-05-31
HLTH	Tema Healthcare AI ETF	Sponsor's file	4.12%	Tema file, 2026-10-13
RXL	ProShares Ultra Health Care	Derivative-based	1.64%	SEC filing, 2026-05-31
CURE	Direxion Daily Healthcare Bull 3X Shares	Derivative-based	1.39%	SEC filing, 2026-07-31
KWIN	KraneShares Wahed Alternative Income Index ETF	Multi-asset	1.06%	SEC filing, 2026-06-30
BAGX	EA Bridgeway Aggressive Investors ETF	Sponsor's file	0.79%	ETF Architect sponsor site file, 2026-09-30
LABU	Direxion Daily S&P Biotech Bull 3X Shares	Derivative-based	0.75%	SEC filing, 2026-07-31
NDOW	Anydrus Advantage ETF	Multi-asset	0.74%	SEC filing, 2026-06-30
FLSP	Franklin Systematic Style Premia ETF	Derivative-based	0.62%	SEC filing, 2026-06-30
KIQQ	KraneShares InspereX Nasdaq Dynamic Buffered High Income Index ETF	Derivative-based	0.61%	SEC filing, 2026-06-30
QB	ProShares Nasdaq-100 Dynamic Buffer ETF	Derivative-based	0.52%	SEC filing, 2026-05-31
IQQQ	ProShares Nasdaq-100 High Income ETF	Derivative-based	0.42%	SEC filing, 2026-05-31
CSM	ProShares Large Cap Core Plus	Derivative-based	0.33%	SEC filing, 2026-05-31
QLD	ProShares Ultra QQQ	Derivative-based	0.31%	SEC filing, 2026-05-31
EQQQ	ProShares Ultra QQQ Equal Weight	Sponsor's file	0.18%	ProShares file, 2026-10-13
AAUB	Alpha Architect US Equity 4 ETF	Sponsor's file	0.18%	ETF Architect sponsor site file, 2026-09-30
SPUU	Direxion Daily S&P 500 Bull 2X Shares	Derivative-based	0.17%	SEC filing, 2026-07-31
NTSD	WisdomTree Efficient U.S. Plus International Equity Fund	Derivative-based	0.17%	SEC filing, 2026-06-30
TQQQ	ProShares UltraPro QQQ	Derivative-based	0.15%	SEC filing, 2026-05-31
FB	ProShares S&P 500 Dynamic Buffer ETF	Derivative-based	0.15%	SEC filing, 2026-05-31
ISPY	ProShares S&P 500 High Income ETF	Derivative-based	0.15%	SEC filing, 2026-05-31
SPXL	Direxion Daily S&P 500 Bull 3X Shares	Derivative-based	0.14%	SEC filing, 2026-07-31
SSO	ProShares Ultra S&P500	Derivative-based	0.11%	SEC filing, 2026-05-31
SSS	Cyber Hornet S&P 500 & Solana 75/25 Strategy ETF	Multi-asset	0.10%	SEC filing, 2026-06-30
JPFP	JPMorgan Managed Futures Plus ETF	Derivative-based	0.08%	SEC filing, 2026-07-31
UPRO	ProShares UltraPro S&P500	Derivative-based	0.08%	SEC filing, 2026-05-31
HRSK	Toews Agility Shares Hedged Risk ETF	Derivative-based	0.07%	SEC filing, 2026-07-31
URSP	ProShares Ultra S&P 500 Equal Weight	Derivative-based	0.07%	SEC filing, 2026-05-31
CGFS	CG Flagship Equity ETF	Sponsor's file	0.05%	ETF Architect sponsor site file, 2026-09-30
CSHP	iShares Dynamic Short-Term Active ETF	Fixed income	0.04%	SEC filing, 2026-07-31

How the ETFs listed apart are read.

What did $100 in VRTX become over three years?

VRTX ended at $140 after 156 weekly closes through 2026-10-13; the dashed line is the $100 put in.

How has VRTX done, year by year?

Year	Total return
2026	+11.8%
2025	+12.6%
2024	-1.0%
2023	+40.9%
2022	+31.5%

Returns and risk

Total return, 1 year	21.6%
Total return, 3 years cumulative	40.1%
Total return, 5 years cumulative	176.3%
Volatility, annualised	30.5%
Worst fall, 3 years	-29.1%
Beta against SPY, 3 years of weekly returns	0.56
Market cap	$122.9B
Price to earnings, trailing	28.3
Dividend yield	0.00%
US stock ETFs holding it	366
Broad ETFs holding it, 500 positions or more	107 of 311

Market cap, price to earnings and yield are reference data; every other figure is computed here from 156 weekly closes.

What would diversify VRTX?

The stocks that have moved least like VRTX over the last 104 weeks, among those held by ten or more covered ETFs: TPC correlates with it at -0.29 and INFU at -0.23, a measurement of co-movement rather than a suggestion.

Ticker	Name	Correlation, 104 weeks
TPC	Tutor Perini Corporation	-0.29moves the opposite way
INFU	InfuSystems Holdings, Inc.	-0.23moves the opposite way
STAA	STAAR Surgical Company	-0.21moves the opposite way
BCO	Brinks Company	-0.19moves the opposite way
DHC	Diversified Healthcare Trust	-0.16moves the opposite way
AMRC	Ameresco, Inc.	-0.15moves the opposite way

What moves with VRTX?

The other end of the same ranking: LLY has moved with VRTX at 0.56, AMGN at 0.49. Each row opens the pair side by side.

Ticker	Name	Correlation, 104 weeks
LLY	Lilly (Eli)	0.56loosely linked
AMGN	Amgen	0.49loosely linked
BIIB	Biogen	0.43loosely linked
AURA	Aura Biosciences, Inc.	0.42loosely linked
MRK	Merck & Co.	0.42loosely linked
KURA	Kura Oncology, Inc.	0.42loosely linked

Weekly total returns, among stocks held by ten or more covered ETFs; closed-end funds are left out of both tables. What the bands mean.

Which ETF has the largest weight in VRTX?

BBH, at 9.10% in its SEC filing for the period ended 2026-06-30, where VRTX is position #3 of 24, followed by IBBQ at 7.66% and IBB at 7.61%.

ETF	Name	Weight	Rank in the ETF	Positions	Holdings dated
BBH	VanEck Biotech ETF	9.10%	#3	24	SEC filing, 2026-06-30
IBBQ	Invesco Nasdaq Biotechnology ETF	7.66%	#3	246	issuer file, 2026-10-12
IBB	iShares Biotechnology ETF	7.61%	#3	237	issuer file, 2026-10-12
GNMX	Corgi Genomics & Precision Medicine ETF	6.71%	#2	58	SEC filing, 2026-06-30
LSGR	Natixis Loomis Sayles Focused Growth ETF	4.78%	#6	21	SEC filing, 2026-06-30
PBE	Invesco Biotechnology & Genome ETF	4.69%	#7	30	issuer file, 2026-10-12
FTXH	First Trust Nasdaq Pharmaceuticals ETF	3.41%	#9	50	SEC filing, 2026-06-30
GNOM	Global X Genomics & Biotechnology ETF	3.33%	#9	50	issuer file, 2026-10-12
BMED	iShares Health Innovation Active ETF	3.27%	#11	54	issuer file, 2026-10-12
IDNA	iShares Genomics Immunology and Healthcare ETF	3.21%	#12	47	issuer file, 2026-10-12

An ETF page opens on every ticker that has one; the others open the fund's JSON file, with its holdings and the date of its issuer file or SEC filing. Run a portfolio x-ray to see how much VRTX you hold across every ETF you own.

VRTX weights from 122 issuer files, dated 2026-08-31 to 2026-10-13, and 244 SEC filings for periods ended 2026-05-29 to 2026-07-31. Prices through 2026-10-13. How every figure here is produced. Measurements, not investment advice.

Cite this page

TickerInside, Vertex Pharmaceuticals (VRTX), holders from each covered fund's own file and from SEC Form N-PORT filings, each dated, prices through 2026-10-13, https://tickerinside.com/stock/vrtx/, CC BY 4.0

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