PBE holdings and overlap
Invesco Biotechnology & Genome ETF (PBE) holds 30 positions in its Invesco file of 2026-10-24. Its three largest are Natera (NTRA) at 6.00%, Illumina (ILMN) at 5.99% and Biogen (BIIB) at 5.68%, and its ten largest make up 49.2% of the fund.
In its Invesco file of 2026-10-24, PBE is 100.0% health care by sector, with none of it in mega-cap tech or in the ten largest US companies by market value. By country, 94.3% of PBE is in the United States, 3.1% in the Netherlands and 2.5% in China.
What does PBE hold, as of its issuer file of 2026-10-24?
Natera is 6.0% of PBE on its own, against a median largest position of 8.6% across the 28 Health Care funds with a page here. The position PBE carries furthest above that group is Illumina at 5.99% of the fund, against a 0.49% median there.
| Rank | Company | Weight | Weight bar |
|---|---|---|---|
| 1 | NTRA Natera | 6.0% | |
| 2 | ILMN Illumina | 5.99% | |
| 3 | BIIB Biogen | 5.68% | |
| 4 | GILD Gilead Sciences | 5.24% | |
| 5 | RPRX Royalty Pharma | 5.14% | |
| 6 | AMGN Amgen | 4.96% | |
| 7 | REGN Regeneron Pharmaceuticals | 4.83% | |
| 8 | VRTX Vertex Pharmaceuticals | 4.74% | |
| 9 | MRNA Moderna | 3.43% | |
| 10 | QGEN Qiagen | 3.15% | |
| 11 | HALO Halozyme Therapeutics | 3.13% | |
| 12 | EXEL Exelixis | 3.1% | |
| 13 | UTHR United Therapeutics Corp | 3.09% | |
| 14 | VCYT Veracyte | 2.97% | |
| 15 | NVAX Novavax | 2.8% | |
| 16 | VCEL Vericel | 2.68% | |
| 17 | TGTX TG Therapeutics | 2.66% | |
| 18 | RGEN Repligen | 2.65% | |
| 19 | SRPT Sarepta Therapeutics | 2.55% | |
| 20 | NBIX Neurocrine Biosciences | 2.54% | |
| 21 | PTGX Protagonist Therapeutics | 2.51% | |
| 22 | LEGN Legend Biotech Corp | 2.47% | |
| 23 | INCY Incyte | 2.43% | |
| 24 | BMRN BioMarin Pharmaceutical | 2.31% | |
| 25 | COLL Collegium Pharmaceutical | 2.28% | |
| 26 | ANAB AnaptysBio | 2.28% | |
| 27 | PTCT PTC Therapeutics | 2.25% | |
| 28 | ARDX Ardelyx | 2.22% | |
| 29 | BCRX BioCryst Pharmaceuticals | 2.12% | |
| 30 | ACAD ACADIA Pharmaceuticals | 1.76% |
The most recent file Invesco has published for PBE is dated 2026-10-24, 4 days before these prices, which is the median for the Invesco ETFs covered here. Every one of the 30 positions PBE holds, with its weight, is in the fund's JSON file. See the other 59 ETFs with a page here that hold NTRA, and how their weights compare with the 6.0% PBE gives it.
Category: Health Care, set by TickerInside from the ETF's own latest file. In its file of 2026-10-24, 100% of its stocks whose sector is known are health care companies, each in the sector the site gives that company. How categories are set.
https://tickerinside.com/api/v1/fund/pbe.jsonhttps://tickerinside.com/api/v1/fund/pbe.csv=IMPORTDATA("https://tickerinside.com/api/v1/fund/pbe.csv")If your sheet uses a decimal comma: =IMPORTDATA("https://tickerinside.com/api/v1/fund/pbe.csv"; ","; "en_US")curl -s https://tickerinside.com/api/v1/fund/pbe.jsonHow much money went into or out of PBE?
On the close of Friday, October 23, 2026, $987 thousand went into PBE, 0.23% of its assets, as it created shares. Over its last 5 closes, a net inflow of $987 thousand.
From PBE's own holdings files. Every ETF's latest flows.
How is PBE split by sector and country?
| Sector | Weight | Weight bar |
|---|---|---|
| Health care | 100.0% |
| Country | Weight | Weight bar |
|---|---|---|
| United States | 94.3% | |
| Netherlands | 3.1% | |
| China | 2.5% |
From its Invesco file of 2026-10-24. How these are measured.
What did PBE hold in its SEC reports since 2019?
In PBE's SEC filings, its largest position went from Biogen (BIIB) at 6.66% on 2019-10-31 to Regeneron Pharmaceuticals (REGN) at 5.47% on 2026-07-31, across 28 quarterly reports.
| Report | Positions | Largest | Top 10 |
|---|---|---|---|
| 2019-10-31 | 29 | BIIB 6.66% | 49.5% |
| 2020-10-31 | 29 | PACB 5.78% | 45.2% |
| 2021-10-31 | 29 | CTLT 5.60% | 46.0% |
| 2022-10-31 | 29 | BIIB 6.98% | 50.2% |
| 2023-10-31 | 30 | VRTX 5.89% | 49.8% |
| 2024-10-31 | 29 | ILMN 5.79% | 45.1% |
| 2025-10-31 | 30 | ILMN 5.71% | 48.2% |
| 2026-07-31 | 30 | REGN 5.47% | 46.2% |
The first report, then the last of each year, of the 28 reports PBE filed on SEC Form N-PORT from 2019-10-31 to 2026-07-31, each company under its ticker today. Every position of every report is in its quarterly file, and at any date at /api/v1/history/pbe/{date}.json. How these are read.
What does PBE duplicate?
The ETF nearest to PBE is FBT: the two hold 45.6% of their weight in common, in the 16 companies both own, and 62.2% of PBE itself is also held there. Owning PBE alongside the ETFs at the top of this table means about half of the weight is held twice.
| ETF | Overlap by weight | Of PBE held there | Of that ETF in PBE | Companies in both | Overlap bar |
|---|---|---|---|---|---|
| FBT | 45.6% | 62.2% | 50.6% | 16 | |
| BBH | 44.6% | 54.4% | 68.3% | 13 | |
| IBB | 42.7% | 84.5% | 54.8% | 25 | |
| IBBQ | 39.5% | 85.5% | 51.9% | 26 | |
| GNOM | 31.6% | 38.9% | 39.2% | 10 | |
| XBI | 29.6% | 78.3% | 29.6% | 24 | |
| BMED | 26.2% | 42.8% | 29.8% | 11 | |
| PJP | 22.2% | 26.1% | 24.2% | 6 | |
| IDNA | 17.2% | 21.3% | 27.1% | 6 | |
| IYH | 15.1% | 68.4% | 15.2% | 17 | |
| IBRN | 14.6% | 14.8% | 20.6% | 5 | |
| RSPH | 13.9% | 37.3% | 13.9% | 8 |
FBT's holdings are from its SEC Form N-PORT for the period ended 2026-06-30, filed 2026-08-21. BBH's holdings are from its SEC Form N-PORT for the period ended 2026-06-30, filed 2026-08-26. The other ETFs' holdings are from their issuers' latest files. Check PBE against any ETF in the ETF overlap calculator · how overlap is measured.
What adds something different to PBE?
RING shares 0% of weight with PBE and its weekly returns correlate with it at 0.28 over three years. The table lists the covered ETFs with the least in common with PBE, least shared weight first and, among equals, lowest correlation.
| ETF | Name | Overlap by weight | Correlation, 3y | Companies in both |
|---|---|---|---|---|
| RING | iShares MSCI Global Gold Miners ETF | 0.0% | 0.28 | 0 |
| SLVP | iShares MSCI Global Silver and Metals Miners ETF | 0.0% | 0.28 | 0 |
| SOXX | iShares Semiconductor ETF | 0.0% | 0.37 | 0 |
| SMIN | iShares MSCI India Small-Cap ETF | 0.0% | 0.37 | 0 |
| PICK | iShares MSCI Global Metals & Mining Producers ETF | 0.0% | 0.44 | 0 |
| PFF | iShares Preferred and Income Securities ETF | 0.0% | 0.47 | 0 |
| IYR | iShares U.S. Real Estate ETF | 0.0% | 0.51 | 0 |
| USRT | iShares Core U.S. REIT ETF | 0.0% | 0.52 | 0 |
Cost, returns and risk
| Expense ratio | 0.59% |
|---|---|
| Dividend yield | 1.37% |
| Total return, 1 year | 38.3% |
| Total return, 3 years cumulative | 85.3% |
| Total return, 5 years cumulative | 40.3% |
| Volatility, annualised | 19.3% |
| Worst fall, 3 years | -19.0% |
| Beta against SPY, 3 years of weekly returns | 0.71 |
| Weight in the ten largest positions | 49.2% |
| Largest single position | 6.0% |
| Assets under management | $0.4B |
Expense ratio, yield and assets are reference data (the expense ratio from PBE's SEC filing of 2026-08-27); the weight in the ten largest positions and the largest single position are from the issuer file of 2026-10-24; every other figure is computed here from weekly closes.
How it moves with the market
| Against | Correlation, 3 years | Covariance, annualised, in percent squared |
|---|---|---|
| SPY | 0.51loosely linked | 137 |
| QQQ | 0.42loosely linked | 157 |
Weekly total returns. What the bands mean · why the covariance is printed.
Year by year
| Year | Total return |
|---|---|
| 2026 | 25.4% |
| 2025 | 24.8% |
| 2024 | 1.1% |
| 2023 | 3.7% |
| 2022 | -10.8% |
One year
Where to go next
- PJP, Invesco Pharmaceuticals ETF
- PPH, VanEck Pharmaceutical ETF
- PSCH, Invesco S&P SmallCap Health Care ETF
- PTH, Invesco Dorsey Wright Healthcare Momentum ETF
- Run a portfolio x-ray to see what PBE carries once you look through it
- Compare PBE against any other ETF in the builder
Holdings from the most recent file Invesco has published, dated 2026-10-24. Prices through 2026-10-28. How every figure here is produced. Measurements, not investment advice.
Cite this page
TickerInside, Invesco Biotechnology & Genome ETF (PBE), holdings from the issuer's file of 2026-10-24, https://tickerinside.com/etf/pbe/, CC BY 4.0
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